I would like to introduce myself as a new member of GSH. I am Tamer Ali, a PostDoc in Phillip Grote's lab. I did my PhD in Gießen in the field of Epigenetics. During that time I studied extensively chromatin biology specifically Drosophila insulators (dCTCF and CP190) by various means such as RNA-seq, ChIP-seq, mass spectrometry, and chromatin 3D structure. Then, I joined Grote's lab to strengthen my background in genetics and to have a new endeavor in the field of lncRNA biology. I am also interested in bioinformatics as a powerful tool to understand the complexity of biological systems on a genome-wide scale. There was a huge leap forward in technology in the last 15 years that shifted the paradigm of biology from gene-specific to genome-wide. This required the development of new programming languages to deal with this enormous data. So besides the wet lab skills, I am able to analyze RNA-seq, scRNA-seq, ChIP-seq, CUT$RUN, ATAC-seq, sc-ATAC-seq using python and R.
Marie-Claire Badouin has acquired her degree in laboratory assistance as chemical assistant at Phillips-University Marburg, where she worked with Prof. Dr. Petersen in the pharmaceutical biology and gained theoretical and practical knowledge of chemistry, biochemistry and molecular biology of the cultivation of plants invitro. Another 3 years she worked in molecular biology as laboratory technician with Prof. Dr. Roland Lill in the Institute for cytobiology and cytopathology, Marburg. Since 2020 Marie-Claire is responsible for targeting constructs cloning, construct validation in cell culture and mES clone screening at our Gene Editing Laboratory. She also performs CRISPR constructs cloning and genetic assays for mutation analysis. Marie-Claire sets up new PCR genotyping protocols and sequencing to screen clones and newly established lines.
Dr. Zhaodai Bai
Dr. Zhaodai Bai is a staff scientist. Zhao has gained his doctoral degree in Department of Human Anatomy, Histology and Embryology, Shandong University (China). He has completed his postdoctoral study on the odorant receptor genes during differentiation of the multipotent cell lines ex vivo in Max Planck research unit for neurogenetics, Frankfurt am Main, with Peter Mombaerts, Ph.D, M.D. Zhao brings his experience in stem cell culturing and in embryo techniques. In TCF he is responsible for mES targeting and clonal cell line generation for chimera models.
As Transgenic Core Facility Specialist, Sandy Eckhardt orchestrates all operations with TCF researchers and inter-laboratory scientists. The execution of microinjections (pronuclear & blastocysts), cryopreservation, in vitro fertilization (IVF) as well as mouse colony management and genotyping are also part of her field of research responsibilities.
Loveth Idemudia graduated from the University of Camerino (Italy) where she bagged both a Bachelor’s Degree in 2015 from the faculty of Bioscience & Biotechnology and a Master's Degree in 2017 from the faculty of Biological science (Molecular Diagnostics). Her Bachelor's dissertation involved the study of evaluation of the antimicrobial activity of novel composite plastics containing silver (I) aclyprazolonato additives. Loveth received her master’s from the University of Camerino and handed in two different theses. One was in Genome analysis in Ciliates: A comparison between Tubulin genes at the University of Camerino and the second one on Functional analysis of genes in the ciliate Tetrahymena thermophilia, which she performed in Toronto (Canada) at the York University. She was a research trainee at the Conway Institute, School of Medicine University College Dublin (Ireland) between October 2018 to January 2019. She carried out studies on the effect of SGLT2 inhibition in human kidney proximal tubular cell-Reno protection in Diabetic Nephropathy. She joined the Prof. Dr. Grote lab in 2022 and will be involved in generating new transgenes and will bring them into mice to develop new biomedical mouse models.
Yi-Hsuan Lin received her Master's degree in Biological Sciences from Goethe University Frankfurt, where she studied long non-coding RNA (lncRNA) during the early stage of cardiogenesis in the lab of Dr. Phillip Grote at the Institute of Cardiovascular Regeneration. She continued as a PhD student starting in 2020 to further investigate one particular lncRNA, that is involved in the splicing of heart specific mRNAs.
Sandra Rogala graduated in Biosciences at Goethe University Frankfurt am Main and worked in the research group of Prof. Dr. Koessl on the intracellular derivation of electrical potentials in the auditory organ of the common grasshopper. At the Neuroscience Center of Goethe University, Sandra worked in the research group of Dr. Momma for her Master's thesis on the effect of cell-cell communication through extracellular vesicles on glioblastoma. Since 2018, Sandra's PhD research focuses on non-coding RNAs (lncRNAs) and their function in the development and maintenance of the cardio-vascular system under standard and stress conditions.