Gustav Speyer, son of Lazard Speyer, who is owner of Frankfurt’s bank ‘Lazard-Speyer-Ellissen’, is born. On December 17th his name is changed into Georg Speyer.

Georg Speyer marries the 24-year-old Franziska Gumbert, eldest daughter of a banker from Berlin. The couple is very interested in social and cultural questions of the day and belongs to Frankfurt’s patrons. Many of Frankfurt’s social clubs and associations go back to their engagement and financial support, even the foundation of Frankfurt’s university and the Georg-Speyer-Haus, institute for biomedical research.

The Speyer family essentially belonged to Frankfurt’s patrons and therefore founded the ‘Georg and Franziska Speyer scholarship foundation’ with a budget of 1 million German Goldmark. Their foundation-supported the ‘maintenance of science, as well as the higher scientific education’ and finally, provided the basis for the University of Frankfurt.

It becomes apparent, that the realization of the academy project would be delayed. Ludwig Darmstaedter, a friend of Paul Ehrlich, prompts Franziska Speyer to give up the original plans and to follow a new concept. He advises her to directly support Paul Ehrlich’s scientific work by founding an institute for biomedical research. Since 1899 Paul Ehrlich had been managing the Royal Institute for experimental therapy in Frankfurt, which controlled the availability of antisera on the market for the state. Since approximately 1902 Ehrlich had dedicated himself to research on drugs for chemotherapeutic therapy of infectious diseases and cancer research.

Grand opening of the Georg-Speyer-Haus and handover to its first director Paul Ehrlich. From now on, Ehrlich manages the Royal Institute for Experimental Therapy as well as the newly opened Georg-Speyer-Haus.

Paul Ehrlich is awarded the Nobel prize for Physiology or Medicine for his ‘everlasting discoveries in medical and biological research, namely the evaluation of serums’.

In honour of Paul Ehrlich, the street in front of ‘his’ institute is renamed to “Paul-Ehrlich-Straße”.

The budget of the ‘Georg-Speyer-Haus’ foundation increases considerably because of the Salvarsan licence.

Opening of the Johann Wolfgang Goethe-University Frankfurt.

Wilhelm Kolle becomes successor of Paul Ehrlich at both institutes until he dies in 1935. Salvarsan is improved to the better-tolerated Neo-Salvarsan.

Ludwig Darmstaedter initiates the separation between the “Georg and Franziska Speyer scholarship foundation“ and the independent and charitable ‘Georg-Speyer-Haus’ foundation to guarantee the returns of Salvarsan licences for the Georg-Speyer-Haus.

Completion of a connective building between the Georg-Speyer-Haus and the nearby Royal Institute for Experimental Therapy and thereby integration of the Ferdinand-Blum-Institut within the complex of buildings.

On the occasion of Ludwig Darmstädter’s 80th birthday the directorate of the Georg-Speyer-Haus decides to establish the ‘Ludwig-Darmstaedter-Preis’.

Richard Otto succeeds Wilhelm Kolle as director of the Georg-Speyer-Haus and of the Royal Institute for Experimental Therapy and manages both institutes until 1948. By order of the Nazi regime all writings of Paul Ehrlich are removed from the institute’s library. At the end of the year all Jewish employees are made redundant by the order of the Reich- and Prussian Ministry of the Interior.

Richard Otto succeeds Wilhelm Kolle as director of the Georg-Speyer-Haus and of the Royal Institute for Experimental Therapy and manages both institutes until 1948. By order of NS regime all writings of Paul Ehrlich are removed from the institute’s library. At the end of the year all Jewish employees are dismissed by the order of the Reich- and Prussian Ministry of the Interior.

Renaming of the ‘Research Institute for Chemotherapy’ to ‘Chemotherapeutical Research Institute Georg-Speyer-Haus’. The institute’s original name and organisational structure of the Twenties are re-established.

Günter K. Schwerin, grandson of Paul Ehrlich, achieved, that the former Royal and meanwhile National Institute for Experimental Therapy is allowed to bear the name of its first director: Paul-Ehrlich-Institut National Institute for Experimental Therapy.

The Georg-Speyer-Haus is allowed to join the Königsberger convention, which defines a common funding of bigger research institutes by the federal states. Therefore, the financial situation of the Georg-Speyer-Haus is stabilised.

Günther Heymann manages the Georg-Speyer-Haus as well as the Paul-Ehrlich-Institute on a temporary basis.

For the second time Günther Heymann becomes the institute’s director on a temporary basis.

Beginning of the relocation of the Paul-Ehrlich-Institute to Langen, dissolution of the union of both institutes and separation between Paul-Ehrlich-Institut and Georg-Speyer-Haus. The management of the Georg-Speyer-Haus decides to continue ist focus using the building in Paul-Ehrlich-Straße.

Hans Dieter Brede directs the Georg-Speyer-Haus on a temporary basis until his death. During his term the entire complex of building is restored by funding from the Federal Ministry of Health and of the Hessian Ministry of Science and Art.

Winfried Wels became director on a temporary basis.

As the new director of the Georg-Speyer-Haus, Florian Greten completely switches the aim of the research to tumor biology. This fact is reflected in the name of the institute ‘Georg Speyer Haus- Institute for Tumor Biology and Experimental Therapy’.