Foto: Andreas Reeg,, +49 171 544 92 47,
Foto: Andreas Reeg,, +49 171 544 92 47,
  • 2022

    Strecker MI, Wlotzka K, Strassheimer F, Roller B, Ludmirski G, König S, Röder J, Opitz C, Alekseeva T, Reul J, Sevenich L, Tonn T, Wels WS, Steinbach JP, Buchholz CJ, Burger MC: AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma. (2022) Oncoimmunology Oct 11;11(1)2127508

    Bemmerlein L, Deniz IA, Karbanova J, Berg-Jacobi A, Drukewitz S, Link T, Goebel A, Sevenich L, Taubenberger A, Wimberger P, Corbeil D and Kulmann JD: Decoding single cell morphology in osteotropic breast cancer cells for dissecting their migratory, molecular and biophysical heterogeneity. (2022) Cancers 14(3):603

  • 2021

    Klemm F, Möckl A, Salamero-Boix A, Alekseeva T, Schäffer A, Schulz M, Niesel K, Maas RR, Groth M, Elie BT, Bowman RL, Hegi ME, Daniel RT, Zeiner PS, Zinke J, Harter PN, Plate KH, Joyce JA* and Sevenich L*. Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis. Nature Cancer, October 18, 2021.
    Nature Cancer

    Schulz M., Sevenich L.
    TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man.
    Frontiers in Immunology. 2021 (12), 716504, eCollection 2021.
    Front. Immunol.

    Niesel K, Schulz M, Anthes J, Alekseeva T, Macas J, Salamero-Boix A, Möckl A, Oberwahrenbrock T, Lolies M, Stein S, Plate KH, Reiss Y, Rödel F, Sevenich L.
    The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis.
    EMBO Mol Med, 2021; 13 (5): e13412, Epub.

    Vasiljeva O, Sevenich L, Reinheckel T.
    Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice.
    Methods Mol Biol, 2021; 2294: 275-293.

  • 2020

    Schulz M, Michels B, Niesel K, Stein S, Farin H, Rödel F, Sevenich L.
    Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response.
    iScience. 2020 Jun 26; 23 (6): 101178, 2020 May 18.

  • 2019

    Schulz M, Salamero-Boix A, Niesel K, Alekseeva T, Sevenich L.
    Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis.
    Front Immunol. 2019 Jul 24; 10:1713,  eCollection 2019.

    Sevenich L.
    Turning “Cold” Into “Hot” Tumors-Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers.
    Front Oncol. 2019 Mar 19; 9: 163, eCollection 2019.

    Chae WH, Niesel K, Schulz M, Klemm F, Joyce JA, Prümmer M, Brill B, Bergs J, Rödel F, Pilatus U, Sevenich L.
    Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis.
    Front Oncol. 2019 Nov 27; 9: 1324, eCollection 2019.

  • 2018

    Sevenich L.
    Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer.
    Front Immunol. 2018 Apr 6; 9: 697.

  • 2016

    Bowman RL, Klemm F, Akkari L, Pyontec SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.
    Macrophage Ontogeny Underlies Differences in Tumor Specific Education in Brain Malignancies.
    Cell Rep. 2016 Nov 22; 17 (9): 2445-2459.

  • 2014

    Sevenich L, Joyce JA.
    Pericellular proteolysis in cancer.
    Genes and Development 28 (21): 2331-47.

    Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA.
    Distinct functions of macrophage- and cancer cell-derived cathepsin Z combine to promote tumor malignancy.
    Genes and Development 28 (19): 2134-50.

    Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massague J, Leslie CS, Joyce JA.
    Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S.
    Nat Cell Biol. 16 (9): 876-888.

    Bengsch F, Buck A, Günther SC, Seiz, JR, Tacke M. Pfeiffer D., von Elversfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T.
    Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
    Oncogene 33 (36): 4474-84.

  • Selected Publications 2006-2013

    Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA.
    CSF-1R inhibition alters macrophage polarization and blocks glioma progression (2013).
    Nat Med. 19 (10): 1264-72.

    Schurigt U, Ellenstein R, Gajda M, Leipner C, Sevenich L, Reinheckel T, Peters C, Wiederanders B, Brauer R.
    Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment (2012).
    Inflamm Res. 61 (9): 1021-9.

    Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T.
    Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice (2011).
    Oncogene 30 (1): 54-64.

    Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T.
    Synergistic anti-tumor effects of cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice (2010).
    PNAS 107 (6): 2497-502.

    Sevenich L*, Hagemann S*, Stoeckle C, Tolosa E, Peters C, Reinheckel T.
    Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knockout mice (2010).
    Biochimie 92 (11): 1674-80.
    *equal contribution

    Schurigt U*, Sevenich L*, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, and Reinheckel T.
    Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model (2010).
    Biol Chem. 389 (8): 1067-74.
    *equal contribution

    Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, and Reinheckel T.
    Reduced tumour cell proliferation and delayed development of high grade mammary carcinomas in cathepsin B-deficient mice (2008).
    Oncogene 27 (30): 4191-9.

    Sevenich L, Pennacchio LA, Peters C, Reinheckel T.
    Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice (2006).
    Biol Chem. 387: 885-891.