Forschen für das Leben
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
  • 2018

    Sevenich L:
    Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer.
    Front Immunol. 2018 Apr 6;9:697.

  • 2016

    Bowman RL, Klemm F, Akkari L, Pyontec SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA,:
    Macrophage Ontogeny Underlies Differences in Tumor Specific Education in Brain Malignancies.
    Cell Rep. 2016 Nov 22;17(9):2445-2459

  • 2014

    Sevenich L, Joyce JA:
    Pericellular proteolysis in cancer.
    Genes and Development 28(21):2331-47.

    Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA:
    Distinct functions of macrophage- and cancer cell-derived cathepsin Z combine to promote tumor malignancy.
    Genes and Development 28(19):2134-50.

    Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massague J, Leslie CS, Joyce JA:
    Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S..
    Nat Cell Biol. 16(9):876-888.

    Bengsch F, Buck A, Günther SC, Seiz, JR, Tacke M. Pfeiffer D., von Elversfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T:
    Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
    Oncogene 33(36):4474-84.

  • Selected Publications 2006-2013

    Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA:
    CSF-1R inhibition alters macrophage polarization and blocks glioma progression (2013).
    Nat Med. 19(10):1264-72.

    Schurigt U, Ellenstein R, Gajda M, Leipner C, Sevenich L., Reinheckel T., Peters C., Wiederanders B, Brauer R:
    Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment (2012).
    Inflamm Res. 61(9):1021-9.

    Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T:
    Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice (2011).
    Oncogene 30(1):54-64.

    Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T:
    Synergistic anti-tumor effects of cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice (2010).
    PNAS 107(6):2497-502.

    Sevenich L*, Hagemann S*, Stoeckle C, Tolosa E, Peters C, Reinheckel T:
    Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knockout mice (2010).
    Biochimie 92(11): 1674-80.
    *equal contribution

    Schurigt U*, Sevenich L*, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, and Reinheckel T:
    Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model (2010).
    Biol Chem. 389(8):1067-74.
    *equal contribution

    Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, and Reinheckel T:
    Reduced tumour cell proliferation and delayed development of high grade mammary carcinomas in cathepsin B-deficient mice (2008).
    Oncogene 27(30):4191-9.

    Sevenich L, Pennacchio LA, Peters C, Reinheckel T:
    Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice (2006).
    Biol Chem. 387: 885-891.