Foto: Andreas Reeg, mail@andreasreeg.com, +49 171 544 92 47, www.andreasreeg.com
Foto: Andreas Reeg, mail@andreasreeg.com, +49 171 544 92 47, www.andreasreeg.com
gsh-henner-farin

3D organoid culture system Our group studies cell signaling in intestinal stem cells and colorectal cancer (CRC), which is the third leading cause of death from cancer among adults. As a model for the healthy and transformed epithelium we use stem cell-derived ‘organoids’: This 3D culture system allows formation of epithelial…[more]

prof-dr-florian-greten

The notion that chronic inflammatory diseases are associated with an elevated risk of tumorigenesis and Rudolf Virchow’s findings in the late 19th century when he described the high frequency of leucocytes in tumor areas led the basis for genetic studies specifically examining the links between inflammation and cancer that had initially…[more]

Metabolic Derangements in Cancer Cancer is marked by dysregulation of the signaling pathways that orchestrate proliferation, cell death, tumor-promoting inflammation, and bioenergetic pathways. Our studies focus on elucidating the host and tumor energy metabolism in pancreatic and intestinal cancer, delineating the critical…[more]

The role of long, non-protein coding RNAs (lncRNAs) in gene and genome regulation The genome encodes all the information required to direct the development of an organism from the fertilized egg into a complex human organism. Mis-regulation in these gene programs can lead to cancer, in children and adults. A novel class of genes, the… [mehr]

Cytotoxic lymphocytes genetically modified to express so-called chimeric antigen receptors (CARs) hold promise for adoptive cancer immunotherapy. CARs are artificial transmembrane proteins that typically contain an extracellular single-chain antibody fragment (scFv) for recognition of antigens on the tumor cell surface, fused to…[more]

gsh-h.medyouf

Under physiological conditions, primitive hematopoietic stem cells reside in anatomically defined areas, referred to as bone marrow niches. The existence of a tightly regulated cross-talk between the complex cellular components of the niche and the HSCs is critical for the maintenance of cellular homeostasis and blood regeneration…[more]

gsh-l.sevenich

Brain metastases are the most common cerebral tumor in adults currently affecting up to 30% of cancer patients. Advanced management of primary tumors has led to increased brain metastases incidence over the past years. Despite the severe clinical issue that is associated with brain metastases, current treatment options remain…[more]

DKTK Research Group for Therapy Resistance Systems Biology of Breast Cancer in Therapy Resistance   Recent integration of tumor devices and high-dimensional computational data from mouse mammary carcinoma studies re-enforced the concept that cancer neighborhood (local tumor microenvironment, TME) can determine efficacy of anti-cancer therapies. We hypothesize that achieving durable cancer control will require systematic… [mehr]

Our research focuses on unraveling the complexity of the interplay between cancer and stromal cells in the tumor microenvironment (TME), as tumors erect multiple barriers to evade immune destruction, resulting in non-responsiveness to treatments. Therefore, we are delving into the roles and regulation of suppressive cell populations to identify vulnerabilities in cancer and stromal cell crosstalk that can be targeted therapeutically….