2024

Kurmasheva, N., Said, A., Wong, B., Kinderman, P., Han, X., Rahimic, A.H.F., Kress, A., Carter-Timofte, M.E., Holm, E., van der Horst, D., Kollmann, C.F., Liu, Z., Wang, C., Hoang, H.-D., Kovalenko, E., Chrysopoulou, M., Twayana, K.S., Ottosen, R.N., Svenningsen, E.B., Begnini, F., Kiib, A.E., Kromm, F.E.H., Weiss, H.J., Di Carlo, D., Muscolini, M., Higgins, M., van der Heijden, M., Bardoul, A., Tong, T., Ozsvar, A., Hou, W.-H., Schack, V.R., Holm, C.K., Zheng, Y., Ruzek, M., Kalucka, J., de la Vega, L., Elgaher, W.A.M., Korshoej, A.R., Lin, R., Hiscott, J., Poulsen, T.B., O’Neill, L.A., Roy, D.G., Rinschen, M.M., van Montfoort, N., Diallo, J.-S., Farin, H.F., Alain, T., and Olagnier, D. (2024). Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways. Nat Commun 15, 4096. https://doi.org/10.1038/s41467-024-48422-x.

Bidaud-Meynard, A., Bourdais, A., Nicolle, O., Duclos, M., Saleh, J., Ruemmele, F.M., Farin, H.F., Delacour, D., Moshous, D., and Michaux, G. (2024). Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine.
Cell Mol Gastroenterol Hepatol 17, 1072–1075. https://doi.org/10.1016/j.jcmgh.2024.02.011.

Menche, C.*, Schuhwerk, H.*, Armstark, I., Gupta, P., Fuchs, K., van Roey, R., Mosa, M.H., Hartebrodt, A., Hajjaj, Y., Clavel Ezquerra, A., Selvaraju, M.K., Geppert, C.I., Bärthel, S., Saur, D., Greten, F.R., Brabletz, S., Blumenthal, D.B., Weigert, A., Brabletz, T.**, Farin, H.F.**, and Stemmler, M.P.** (2024). ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer. EMBO reports, 1–26. https://doi.org/10.1038/s44319-024-00186-7.
* first authors
** corresponding authors

2022

Boonsanay, V., Mosa, M.H., Looso, M., Weichenhan, D., Ceteci, F., Pudelko, L., Lechel, A., Michel, C.S., Künne, C., Farin, H.F., Plass, C., Greten, F.R., 2022. Loss of SUV420H2-dependent chromatin compaction drives right-sided colon cancer progression. Gastroenterology.

2021

2020

2019

Hoang VT, Verma D, Godavarthy PS, Llavona P, Steiner M, Gerlach K, Michels BE, Bohnenberger H, Wachter A, Oellerich T, Müller-Kuller U, Weissenberger E, Voutsinas JM, Oehler VG, Farin HF, Zörnig M, Krause DS.
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia 33, 1700-1712, 2019.
Leukemia by Springer Nature

Schwiebs A, Juan MHS, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Oncogene 38, 4788-4803, 2019.
Oncogene by Springer Nature

Schnalzger TE, de Groot MH, Zhang C, Mosa MH, Michels BE, Röder J, Darvishi T, Wels WS, Farin HF.
3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids.
The EMBO Journal 38: e100928, 2019.
EMBO or download PDF

Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF.
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.
J Exp Med. 2019, 216(3): 704-720.
JEM

Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D.
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
Gastroenterology, 2019, 156(1), 275–278.
Gastroenterology by AGA institute

2018

Mosa, M.H., Nicolle, O., Maschalidi, S., Sepulveda, F.E., Bidaud-Meynard, A., Menche, C., Michels, B.E., Michaux, G.*, Basile, G. de S.*, Farin H.F.*
Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids.
Cellular and Molecular Gastroenterology and Hepatology, V6/4, p. 477-493, 2018.
CMGH

2017

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M.
YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Proc Natl Acad Sci USA, 2017 Feb 14; 114(7): 1643-1648. doi: 10.1073/pnas.1620290114.
PubMed

2016

Tetteh, P.W., Kretzschmar, K., Begthel, H., Born, M. van den, Korving, J., Morsink, F., Farin H.F., Es, J.H. van, Offerhaus, G.J.A., and Clevers, H.
Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.
PNAS 201614057, 2016.
PubMed

Greulich, F., Rudat, C., Farin H.F., Christoffels, V.M., and Kispert, A.
Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.
PLoS ONE 11, e0156787, 2016.
PubMed

Greulich, F., Trowe, M.-O., Leffler, A., Stoetzer, C., Farin H.F., and Kispert, A.
Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
J. Mol. Cell. Cardiol. 97, 140–149, 2016.
PubMed

Farin H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J., Maurice, M.M., et al.
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.
Nature 530, 340–343.
PubMed

Tetteh, P.W., Basak, O., Farin H.F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J.H., et al.
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.
Cell Stem Cell 18, 203–213, 2016.
PubMed

2015

Weren RDA, Venkatachalam R, Cazier J-B, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ETP, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KKH, Carvajal-Carmona L, Nagtegaal ID, Schackert HK, Clevers H, van de Wetering M, Tomlinson IP, Ligtenberg MJL, Hoogerbrugge N, Geurts van Kessel A, Kuiper RP.
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
J. Pathol. 236: 155–164, 2015.
PubMed

Tetteh PW, Farin HF, and Clevers H.
Plasticity within stem cell hierarchies in mammalian epithelia.
Trends Cell Biol. Oct 9. pii: S0962-8924(14)00161-5, review article, 2015.
PubMed

2014

Lemoine R, Pachlopnik-Schmid J, Farin HF, Bigorgne A, Debré M, Sepulveda F, Héritier S, Lemale J, Talbotec C, Rieux-Laucat F, Ruemmele F, Morali A, Cathebras P, Nitschke P, Bole-Feysot C, Blanche S, Brousse N, Picard C, Clevers H, Fischer  A, de Saint Basile G.
Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency.
J Allergy Clin Immunol. 134: 1354-1364, 2014.
PubMed

Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.
Stem Cell Reports 2: 838–852, 2014.
PubMed

Farin HF*, Karthaus WR*, Kujala P, Rakhshandehroo M, Vries R, Kalkhoven E, Nieuwenhuis EES, Clevers H.
Secretion of antimicrobial Paneth cell products is directly controlled by immune cell-derived Interferon-gamma.
Journal of Experimental Medicine, 2014 Jun 30; 211(7): 1393-405.
Pubmed

Yin X, Farin HF, Es JH, Clevers H, Langer R, Karp JM.
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
Nature Methods. 2014 Jan; 11(1): 106-12. doi: 10.1038/nmeth.2737.
Pubmed

* = equal contribution

2013

Bigorgne AE*, Farin HF*, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, Berrebi D, Bole-Feysot C, Nischke P, Brousse N, Fischer A, Clevers H, de Saint Basile G.
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. Journal of Clinical Investigation.
2013 Dec 2. pii: 71471. doi: 10.1172/JCI71471. [Epub ahead of print]
Pubmed

Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ.
Generation of L-cells in mouse and  human small intestine organoids.
Diabetes. 2013 Oct 15. [Epub ahead of print]
PubMed

de Groot RE, Farin HF, Macrková M, van Es JH, Clevers HC, Korswagen HC.
Retromer dependent recycling of the wnt secretion factor wls is dispensable for stem cell maintenance in the Mammalian intestinal epithelium.
PLoS One. 2013 Oct  9; 8(10): e76971. doi: 10.1371/journal.pone.0076971.
PubMed

Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A.
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.
PLoS Genetics. 2013; 9(4): e1003467. doi: 10.1371/journal.pgen.1003467.
PubMed

Lüdtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A.
Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.
PLoS Genetics. 2013; 9(1): e1003189. doi: 10.1371/journal.pgen.1003189.
PubMed

2012

Greulich F, Farin HF, Schuster-Gossler K, Kispert A.
Tbx18 function in epicardial development.
Cardiovascular Research. 2012 Dec 1; 96(3): 476-83. doi: 10.1093/cvr/cvs277.
PubMed

Farin HF, Van Es JH, Clevers H.
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
Gastroenterology. 2012 Dec; 143(6): 1518-1529.e7. doi: 10.1053/j.gastro.2012.08.031.
PubMed

Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A.
Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Development. 2012 Sep; 139(17): 3099-108. doi: 10.1242/dev.077388.
PubMed

Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, ‘t Hoen PA, Kispert A, Christoffels VM.
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial  cushion formation.
Cellular and Molecular Life Sciences. 2012 Apr; 69(8): 1377-89. doi: 10.1007/s00018-011-0884-2.
PubMed

Selected Publications 2007-2011

Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.
Controlled gene expression in primary Lgr5 organoid cultures.
Nature Methods. 2011 Dec 4; 9(1): 81-3. doi: 10.1038/nmeth.1802.
PubMed

Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A.
Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme.
Human Molecular Genetetics 2010 Dec 15; 19(24): 4918-29. doi: 10.1093/hmg/ddq426.
PubMed

Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A.
Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
Circulation Research. 2009 Aug 28; 105(5): 442-52. doi: 10.1161/CIRCRESAHA.109.196063.
PubMed

Lausch E, Hermanns P, Farin HF, Alanay Y, Unger S, Nikkel S, Steinwender C, Scherer G, Spranger J, Zabel B, Kispert A, Superti-Furga A.
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in  Cousin syndrome.
American Journal of Human Genetics. 2008 Nov; 83(5): 649-55. doi: 10.1016/j.ajhg.2008.10.011.
PubMed

Farin HF, Mansouri A, Petry M, Kispert A.
T-box protein Tbx18 interacts with  the paired box protein Pax3 in the development of the paraxial mesoderm.
Journal of Biological Chemistry. 2008 Sep 12; 283(37): 25372-80. doi: 10.1074/jbc.M802723200.
PubMed

Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A.
Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
Journal of Biological Chemistry. 2007 Aug 31; 282(35): 25748-59.
PubMed