Research
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247, andreas.reeg@t-online.de, www.andreasreeg.de
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247, andreas.reeg@t-online.de, www.andreasreeg.de Forschen für das Leben
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +49-171-5449247, andreas.reeg@t-online.de, www.andreasreeg.de
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247, andreas.reeg@t-online.de, www.andreasreeg.de
  • 2021

    Allou, L., Balzano, S., Magg, A., Quinodoz, M., Royer-Bertrand, B., Schöpflin, R., Chan, W., Speck-Martins, C.E., Carvalho, D.R., Farage, L., et al. …. Grote, P., Rivolta, C., Mundlos S and Superti-Furga Andrea.
    Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
    Nature 592, 93–98, 2021.
    Nature

  • 2020

    Ali T, Grote P.
    Beyond the RNA-dependent function of LncRNA genes.
    eLife 9, 1-14, 2020.
    eLife or click here for download

    Rieke J.M., Zhang R., Braun D., Yilmaz Ö., Japp A.S., Lopes F.M., Pleschka M., Hilger A.C., Schneider S., Newman W.G., ··· , Grote P., Zwink N., Jenetzky E., Brusco A., Thiele H., Ludwig M., Schweizer U., Woolf A.S., Odermatt B. and Reutter H.
    SLC20A1 Is Involved in Urinary Tract and Urorectal Development.
    Front. Cell Dev. Biol. 8, 1–16, 2020.
    Front. Cell Dev. Biol. or click here for download

    Zhang R., Gehlen J., Kawalia A., Melissari M.T., Dakal T.C., Menon A.M., Höfele J., Riedhammer K., Waffenschmidt L., Fabian J., ··· , Grote P., Schumacher J., Thiele H., Reutter H.
    Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia.
    PLOS ONE 15, 1–14.
    PLOS ONE

  • 2019

    Ritter N.*, Ali T.*, Kopitchinski N., Schuster P., Beisaw A., Hendrix D.A., Schulz M.H., Müller-McNicoll M., Dimmeler S. and Grote P.
    The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development.
    Dev. Cell, V50, I5, 644-657.E8, 2019.
    Developmental Cell

    Fischer C., Metsger M., Bauch S., Vidal R., Böttcher M., Grote P., Kliem M. and Sauer S.
    Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells.
    Sci Signal, V12I581, eaao5820, 2019.
    Science Signaling

    Kolvenbach C.M., Dworschak G.C., Frese S., Japp A.S., Schuster P., Wenzlitschke N., Yilmaz Ö., Lopes F.M., Pryalukhin A., Schierbaum L., . . . Grote P., Zaniew M., Odermatt B. and Hilger A.
    Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction.
    AJHG, V104, I5, 994–1006, 2019.
    The American Journal of Human Genetics or click here for PDF

    Mirtschink P., Bischof C., Pham M.-D., Sharma R., Khadayate S., Rossi G., Fankhauser N., Traub S., Sossalla S., Hagag E., Berthonneche C., Sarre A., Stehr S.N., Grote P., Pedrazzini T., Dimmeler S., Krek W and Krishnan J.
    Inhibition of the HIF1α-Induced Cardiospecific HERNA1 eRNA Protects from Heart Disease.
    Circulation, V139, No. 24, 2778–2792, 2019.
    Circulation or click here for PDF

  • 2018

    Phillip Grote* and Reinier A. Boon*.
    LncRNAs Coming of Age.
    Circ. Res, V123, No. 5, 535–537, 2018.
    Circulation Research

    Neumann P., Jaé N., Knau A., Glaser S.F., Fouani Y., Rossbach O., Krüger M., John D., Bindereif A., Grote P., et al.
    The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.
    Nat Commun 9, 237, 1-12, 2018.
    Nature Communications or click here for PDF

  • 2017

    Beisaw A., Tsaytler P., Koch F., Schmitz S.U., Melissari M.-T., Senft A.D., Wittler L., Pennimpede T., Macura K., Herrmann B.G. and Grote P.
    BRACHYURY directs histone acetylation to target loci during mesoderm development.
    EMBO Rep. 19, 118-134, e201744201, 2017.
    EMBO Reports or click here for PDF

    Koch F., Scholze M., Wittler L., Schifferl D., Sudheer S., Grote P., Timmermann B., Macura K. and Herrmann B.G.
    Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors.
    Dev. Cell V42, I5, 514–526.E7, 2017.
    Developmental Cell

    Bischoff F.C., Werner A., John D., Boeckel J.-N., Melissari M.-T., Grote P., Glaser S.F., Demolli S., Uchida S., Michalik K.M. et al.
    Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
    Circ. Res V121, No. 4, 368–375, 2017.
    Circulation Research

  • 2016

    Sudheer S., Liu J., Marks M., Koch F., Anurin A., Scholze M., Senft A.D., Wittler L., Macura K., Grote P. et al.
    Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm.
    Stem Cells V34, I7, 1790–1800, 2016.
    Stem Cells

    Schmitz S.U., Grote P. and Herrmann B.G.
    Mechanisms of long noncoding RNA function in development and disease.
    Cell. Mol. Life Sci., V73, I6, 2491–2509, 2016.
    Cellular & Molecular Life Sciences or click here for PDF

    Melissari M.-T. and Grote P.
    Roles for long non-coding RNAs in physiology and disease.
    Pflugers Arch – Eur J Physiol 468, 945–958, 2016.
    Pflügers Archiv – European Journal of Physiology

  • 2015

    Marks M., Pennimpede T., Lange L., Grote P., Herrmann B. G. & Wittler, L.
    Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function.
    Gene, V575, I2, 438-451, 2016.
    Gene

    Grote P. & Herrmann, B. G.
    Long noncoding RNAs in organogenesis: making the difference.
    TiG, V31, I6, 329-335, 2015.
    Trends in Genetics

  • 2014

    Schwartz B., Marks M., Wittler L., Werber M., Währisch S., Nordheim A., Herrmann B.G. and Grote P.
    SRF is essential for mesodermal cell migration during elongation of the embryonic body axis.
    Mechanisms of Development, V133, 23–35, 2014.
    Mechanisms of Development or click here for download

    Werber M, Wittler L, Timmermann B, Grote P*, Herrmann BG*.
    The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.
    Development, V141, I11, 2325–2330, 2014.*Corresponding authors
    Development

  • 2013

    Grote P, Herrmann BG.
    The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis.
    RNA Biol, V10, I10, 1579–1585, 2013.
    RNA Biology

    Grote P., Wittler L., Hendrix D., Koch F., Währisch S., Beisaw A., Macura K., Bläss G., Kellis M., Werber M. et al.
    The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.
    Dev Cell V24, I2, 206–214, 2013.
    Developmental Cell

    Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Dietrich J, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M.
    DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer.
    PLoS Genet, V9, I2, e1003250, 1-14, 2013.
    PLoS Genetics or click here for PDF

  • 2012 AND OLDER

    Vidigal J. A., Morkel M., Wittler L., Brouwer-Lehmitz A., Grote P., Macura K. and Herrmann B.G.
    An inducible RNA interference system for the functional dissection of mouse embryogenesis.
    Nucleic Acids Res. V38, I11, e122, 1-7, 2010.
    Nucleic Acids Research or click here for download

    Wittler L., Shin E.H., Grote P., Kispert A., Beckers A., Gossler A., Werber M. and Herrmann B.G.
    Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.
    EMBO Rep, V8, I8, 784–789, 2007.
    EMBO Reports or click here for PDF

    Grote P. and Conradt B.
    The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans.
    Dev Cell V11, I4, 561–573, 2006. Faculty of 1000 – recommended article
    Development Cell

  • [Publications are currently being revised]