2023

Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabo L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brune B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Muller S, Knapp S, Trajanoski Z, Greten FR. Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses. Cancer Discov. 2023 Oct 5;13(10):2192-2211
PubMed.

Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Greten FR: Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade. GUT 2023 Sep;72(9):1774-1782.
PubMed.

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Herrmann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer KH, Kestner RI, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, Vehreschild MJGT, Weigert A, Wild PJ, Zeuzem S, Engelmann C; ACLF-I investigators; Schaefer L, Welsch C, Trebicka J. Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure. Am J Physiol Cell Physiol. 2023 Jul 1;325(1):C129-C140
American Physiological Society.

Vornholz L, Isay SE, Kurgyis Z, Strobl DC, Loll P, Mosa MH, Luecken MD, Sterr M, Lickert H, Winter C, Greten FR, Farin HF, Theis FJ, Ruland J. Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. Sci Adv. 2023 Mar 17;9(11):eadd8564
PubMed.

2022

Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR. Loss of SUV420H2-dependent chromatin compaction drives right-sided colon cancer progression. Gastroenterology. 2022 Nov 16:S0016-5085(22)01265-3. doi: 10.1053/j.gastro.2022.10.036.
PubMed

Kennel KB, Bozlar M, De Valk AF, Greten FR. Cancer-associated fibroblasts in inflammation and anti-tumor immunity. Clin Cancer Res. 2022 Nov 18. doi: 10.1158/1078-0432.
PubMed

Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas A, Kennel KB, Engel E, Dabiri Y, Schewe M, Kirisozu A, Petrocelli V, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Colon tumor cell death causes mTOR dependence by pararcrine P2X4 stimulation. Nature, 2022, in press
Nature

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs, K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux P, Rinsch C, Greten FR (2022) Expansion of T memory stem cells with superior antitumor immunity by Urolithin Ainduced mitophagy, Immunity, 2022, in press
ScienceDirect

Jaitner S, Pretzsch E, Neumann J, Schäffauer A, Schiemann M, Angele M, Kumbrink J, Schwitalla S, Greten FR, Brandl L, Klauschen F, Horst D, Kirchner T, Jung A. J Pathol Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer. Clin Res. 2022 Nov 8
PubMed

Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR.; Image-guided radiotherapy in an orthotopic mouse model of rectal cancer.  STAR Protoc. 2022 Oct 5;3(4):101749.
PubMed

Denk D, Greten FR.: Inflammation: the incubator of the tumor microenvironment. Trends Cancer. 2022 Jul 27:S2405-8033(22)00154-6.
PubMed

Fleischmann M, Diefenhardt M, Nicolas AM, Rödel F, Ghadimi M, Hofheinz RD, Greten FR, Rödel C, Fokas E; ACO/ARO/AIO-21 – Capecitabine-based chemoradiotherapy in combination with the IL-1 receptor antagonist anakinra for rectal cancer Patients: A phase I trial of the German rectal cancer study group. Clin Transl Radiat Oncol. 2022 Apr 6;34:99-106.
PubMed

Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell. 2022 Feb 14;40(2):168-184.e13.
PubMed

Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Rep. 2022 Mar 1;38(9):110471.
PubMed

Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis. Cancer Res. 2022 Apr 1;82(7):1380-1395.
CancerRes

Berlin, C., Cottard, F., Willmann, D., Urban, S., Tirier, S., Marx, L., Rippe, K., Schmitt, M., Petrocelli, V., Greten, FR, Fichtner-Feigl, S., Kesselring, R., Metzger, E., Schüle, R. KMT9 controls stemness and growth of colorectal cancer. Cancer Res. 2022 Jan 15;82(2):210-220
PubMed

2021

Kennel KB, Greten FR., Immune cell – produced ROS and their impact on tumor growth and metastasis, Redox Biol, 2021 Feb 5;101891.
PubMed

Schmitt M., Greten FR.: The Inflammatory pathogenesis of colorectal cancer, Nature Reviews Immunology, 2021, 21(10):653-667
PubMed

Neufert C, Heichler C, Brabletz T, Scheibe K, Boonsanay V, Greten FR, Neurath MF. Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis. Nat Protoc. 2021 Jan;16(1):61-85
PubMed

2020

Mosa MH, Michels BE, Menche C, Nicolas AM, Darvishi T, Greten FR., Farin HF. A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer. Cancer Res. 2020 Oct 14:canres.0263.2020.
PubMed

Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR. AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.  J Exp Med. 2020 Oct 5;217(10): e20191515
PubMed

Olesch C, Sirait-Fischer E, Berkefeld M, Fink AF, Susen RM, Ritter B, Michels BE, Steinhilber D, Greten FR, Savai R, Takeda K, Brüne B, Weigert A. S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion. J Clin Invest. 2020 Oct 1;130(10): 5461-5476
PubMed

Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. Fructose stimulated de novo lipogenesis is promoted by inflammation.  Nat Metab. 2020 Oct;2(10):1034-1045.
PubMed

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 Mar;20(3):174-186.
PubMed

2019

Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis. Gut. 2019 Nov 4. pii: gutjnl-2019-319200
PubMed

Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
Greten FR, Grivennikov SI.
Immunity. 2019 Jul 16;51(1):27-41.
PubMed

Modulating inflammation for cancer therapy.
Ritter B, Greten FR.
J Exp Med. 2019 Jun 3;216(6):1234-1243.
PubMed

Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.
De Oliveira T, Ramakrishnan M, Diamanti MA, Ziegler PK, Brombacher F, Greten FR.
Oncogene. 2019 Mar;38(11):1787-1801.
PubMed

2018

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.
Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM.
Cancer Cell. 2018 Aug 13;34(2):298-314.e7.
PubMed

Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis.
Finkelmeier F, Canli Ö, Peiffer KH, Walter D, Tal A, Koch C, Pession U, Vermehren J, Trojan J, Zeuzem S, Piiper A, Greten FR, Grammatikos G, Waidmann O.
PLoS One. 2018 Jul 16;13(7):e0200855.
PubMed

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.
Cell. 2018 Jun 11. pii: S0092-8674(18)30640-8.
PubMed

Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.
Neumann T, Canli Ö, Greten FR.
Oncotarget. 2018 Mar 30;9(24):16775-16791.
PubMed

2017

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Canli Ö, Nikolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR.
Cancer Cell. 2017 Dec;32(6):869-883.
Article at Science Direct

Cell plasticity in epithelial homeostasis and tumorigenesis.
Varga J, Greten FR.
Nat Cell Biol. 2017 Oct;19(10):1133-1141. doi: 10.1038/ncb3611.
PubMed

Mesenchymal Cells in Colon Cancer.
Koliaraki V, Pallangyo CK, Greten FR, Kollias G.
Gastroenterology. 2017 Apr;152(5):964-979. doi: 10.1053/j.gastro.2016.11.049.
PubMed

Cancer: Tumour stem-cell surprises.
Greten FR.
Nature. 2017 Mar 29;543(7647):626-627. doi: 10.1038/543626a.
No abstract available.

EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
Gastroenterology. 2017 Apr 8. pii: S0016-5085(17)35414-8. doi:10.1053/j.gastro.2017.03.053.
PubMed

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR.
J Exp Med. 2017 Jan 12. pii: jem.20161867. doi: 10.1084/jem.20161867.
PubMed

2016

High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.
Finkelmeier F, Canli Ö, Tal A, Pleli T, Trojan J, Schmidt M, Kronenberger B, Zeuzem S, Piiper A, Greten FR, Waidmann O.
Eur J Cancer. 2016 May;59:152-9. doi: 10.1016/j.ejca.2016.03.002.
PubMed

The Irony of Tumor-Induced Inflammation.
Greten FR.
Cell Metab. 2016 Sep 13;24(3):368-9. doi: 10.1016/j.cmet.2016.08.025.
PubMed

Inflammation and cancer: tissue regeneration gone awry.
Pesic M, Greten FR.
Curr Opin Cell Biol. 2016 Dec;43:55-61. doi: 10.1016/j.ceb.2016.07.010. Review.
PubMed

Lifting the Mist on Gastric Stem Cells.
Varga J, Greten FR.
Cell Stem Cell. 2016 Jan 7;18(1):7-9. doi: 10.1016/j.stem.2015.12.008.
PubMed

2015

Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics.
Vogler N, Bocklitz T, Subhi Salah F, Schmidt C, Bräuer R, Cui T, Mireskandari M, Greten FR, Schmitt M, Stallmach A, Petersen I, Popp J.
J Biophotonics. doi: 10.1002/jbio.201500237.
PubMed

IKKß acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
PallangyoC, ZieglerP, Greten FR.
JEM, 212(13):2253-66.
PubMed

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Canli Ö, Alankuş YB, Grootjans S, Vegi N, Hültner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW, Greten FR.
Blood, 2015 Oct 13. pii: blood-2015-06-654194.
PubMed

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases. Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T.
Oncotarget 6(30):28833-50.
PubMed

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.
Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.
Oncotarget 6:5354-68.
PubMed

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang L.M., East J.E., Tomlinson I., Leedham S.
Nat Med 21:67-70.
PubMed

2014

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC.
Nature 514:508-12.
PubMed

Selective in vivo imaging of tumors with a tumor cell-specific Hsp70 peptide-based probe.
Stangl S, Varga J, Freysold B, Traijkovic-Arsic M, Siveke JT, Greten FR, Ntziachristos V, Multhof, G.
Cancer Res 74:6903-12.
PubMed

Varga J, De Oliveira T, Greten FR.
The architect who never sleeps: Tumor-induced plasticity.
FEBS Lett 588: 2422-2427.
PubMed

Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
J Clin Invest 124: 1853-1867.
PubMed

Greten FR.
YAP1 Takes Over when Oncogenic K-Ras Slumbers.
Cell 158: 11-12.
PubMed

Goktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR.
IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Cell Rep 7: 1914-1925.
PubMed

2013

Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR.
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Cancer Cell 23: 93-106.
PubMed

Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Cell 152: 25-38.
PubMed

Quante M, Varga J, Wang TC, Greten FR.
The gastrointestinal tumor microenvironment.
Gastroenterology 145: 63-78.
PubMed

Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M.
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Cancer Cell 24: 257-271.
PubMed

Neufert C, Becker C, Tureci O, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF.
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
J Clin Invest 123: 1428-1443.
PubMed

Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.
ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Cell Stem Cell 12: 761-773.
PubMed

Glatz J, Varga J, Garcia-Allende PB, Koch M, Greten FR, Ntziachristos V.
Concurrent video-rate color and near-infrared fluorescence laparoscopy.
J Biomed Opt 18: 101302.
PubMed

2011

Mankan AK, Greten FR.
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.
Expert Opin Investig Drugs 20: 1263-1275.
PubMed

Mankan AK, Canli O, Schwitalla S, Ziegler P, Tschopp J, Korn T, Greten FR.
TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.
Proc Natl Acad Sci U S A 108: 6567-6572.
PubMed

Kriegl L, Neumann J, Vieth M, Greten FR, Reu S, Jung A, Kirchner T.
Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.
Mod Pathol 24: 1015-1022.
PubMed

Greten FR.
TAK1: Another mesh in the NF-kappaB – JNK controlled network causing hepatocellular carcinoma.
J Hepatol 55: 721-723.
PubMed

Fang HY, Greten FR.
Cell Autonomous and Non-Autonomous Functions of IKKbeta and NF-kappaB during the Pathogenesis of Gastrointestinal Tumors.
Cancers (Basel) 3: 2214-2222.
PubMed

Arkan MC, Greten FR.
IKK- and NF-kappaB-mediated functions in carcinogenesis.
Curr Top Microbiol Immunol 349: 159-169.
PubMed

2010

Scheibel M, Klein B, Merkle H, Schulz M, Fritsch R, Greten FR, Arkan MC, Schneider G, Schmid RM.
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
J Exp Med 207: 2621-2630.
PubMed

Grivennikov SI, Greten FR, Karin M.
Immunity, inflammation, and cancer.
Cell 140: 883-899.
PubMed

Greten FR, Karin M.
Peering into the aftermath: JAKi rips STAT3 in cancer.
Nat Med 16: 1085-1087.
PubMed

Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR.
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Cancer Cell 18: 135-146.
PubMed

2009

Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Kloppel G, Sipos B, Greten FR, Arkan MC.
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Proc Natl Acad Sci U S A 106: 3354-3359.
PubMed

Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE.
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Blood 114: 844-859.
PubMed

Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR.
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
Cancer Cell 15: 91-102.
PubMed

Bollrath J, Greten FR.
IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.
EMBO Rep 10: 1314-1319.
PubMed

Selected Publications 2001 – 2008

Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Proc Natl Acad Sci U S A 105: 15058-15063, 2008.
PubMed

Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D.
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Nature 446: 552-556, 2007.
PubMed

Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Goktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O’Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M.
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 130: 918-931, 2007.
PubMed

Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, Schmid RM.
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.
Embo j 25: 3801-3812, 2006.
PubMed

Garbe AI, Vermeer B, Gamrekelashvili J, von Wasielewski R, Greten FR, Westendorf AM, Buer J, Schmid RM, Manns MP, Korangy F, Greten TF.
Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses.
Cancer Res 66: 508-516, 2006.
PubMed

von Wichert G, Haeussler U, Greten FR, Kliche S, Dralle H, Bohm BO, Adler G, Seufferlein T.
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.
Oncogene 24: 1284-1289, 2005.
PubMed

Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M.
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis–CREB and NF-kappaB as key regulators.
Immunity 23: 319-329, 2005.
PubMed

Karin M, Greten FR.
NF-kappaB: linking inflammation and immunity to cancer development and progression.
Nat Rev Immunol 5: 749-759, 2005.
PubMed

Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M.
IKK-beta links inflammation to obesity-induced insulin resistance.
Nat Med 11: 191-198, 2005.
PubMed

Greten FR, Karin M.
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer.
Cancer Lett 206: 193-199, 2004.
PubMed

Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M.
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Cell 118: 285-296, 2004.
PubMed

Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF.
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
Proc Natl Acad Sci U S A 101: 2452-2457, 2004.
PubMed

Schreiner B, Greten FR, Baur DM, Fingerle AA, Zechner U, Bohm C, Schmid M, Hameister H, Schmid RM.
Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci.
Oncogene 22: 6802-6809, 2003.
PubMed

Schreiner B, Baur DM, Fingerle AA, Zechner U, Greten FR, Adler G, Sipos B, Kloppel G, Hameister H, Schmid RM.
Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice.
Genes Chromosomes Cancer 38: 240-248, 2003.
PubMed

Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M.
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Nat Med 9: 575-581, 2003.
PubMed

Wagner M, Weber CK, Bressau F, Greten FR, Stagge V, Ebert M, Leach SD, Adler G, Schmid RM.
Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells.
Gastroenterology 122: 1898-1912, 2002.
PubMed

Schneider G, Oswald F, Wahl C, Greten FR, Adler G, Schmid RM.
Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter.
J Biol Chem 277: 43599-43607, 2002.
PubMed

Park JM, Greten FR, Li ZW, Karin M.
Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.
Science 297: 2048-2051, 2002
PubMed

Karin M, Cao Y, Greten FR, Li ZW.
NF-kappaB in cancer: from innocent bystander to major culprit.
Nat Rev Cancer 2: 301-310, 2002.
PubMed

Greten FR, Weber CK, Greten TF, Schneider G, Wagner M, Adler G, Schmid RM.
Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.
Gastroenterology 123: 2052-2063, 2002.
PubMed

Wagner M, Greten FR, Weber CK, Koschnick S, Mattfeldt T, Deppert W, Kern H, Adler G, Schmid RM.
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.
Genes Dev 15: 286-293, 2001.
PubMed

Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M.
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Science 293: 1495-1499, 2001.
PubMed

Seitz U, Wagner M, Vogg AT, Glatting G, Neumaier B, Greten FR, Schmid RM, Reske SN.
In vivo evaluation of 5-[(18)F]fluoro-2′-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
Cancer Res 61: 3853-3857, 2001.
PubMed

Greten FR, Wagner M, Weber CK, Zechner U, Adler G, Schmid RM.
TGF alpha transgenic mice. A model of pancreatic cancer development.
Pancreatology 1: 363-368, 2001.
PubMed

Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M.
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cell 107: 763-775, 2001.
PubMed