Foto: Andreas Reeg,, +49 171 544 92 47,
Foto: Andreas Reeg,, +49 171 544 92 47,
  • 2023

    Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression.
    Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR. Gastroenterology. 2023 Feb;164(2):214-227. doi: 10.1053/j.gastro.2022.10.036. Epub 2022 Nov 17. PMID: 36402192 Free PMC article.
    Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
    Ahmed A, Reinhold C, Breunig E, Phan TS, Dietrich L, Kostadinova F, Urwyler C, Merk VM, Noti M, Toja da Silva I, Bode K, Nahle F, Plazzo AP, Koerner J, Stuber R, Menche C, Karamitopoulou E, Farin HF, Gollob KJ, Brunner T. Mol Oncol. 2023 Mar 1. doi: 10.1002/1878-0261.13414. Online ahead of print. PMID: 36861295 Free article.
    Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.
    Vornholz L, Isay SE, Kurgyis Z, Strobl DC, Loll P, Mosa MH, Luecken MD, Sterr M, Lickert H, Winter C, Greten FR, Farin HF, Theis FJ, Ruland J. Sci Adv. 2023 Mar 17;9(11):eadd8564. doi: 10.1126/sciadv.add8564. Epub 2023 Mar 15. PMID: 36921054 Free PMC article.
    Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
    Tredup C, Ndreshkjana B, Schneider NS, Tjaden A, Kemas AM, Youhanna S, Lauschke VM, Berger BT, Krämer A, Berger LM, Röhm S, Knapp S, Farin HF, Müller S. ACS Chem Biol. 2023 Apr 21;18(4):822-836. doi: 10.1021/acschembio.2c00877. Epub 2023 Mar 21. PMID: 36944371 Free PMC article.
    Farin HF *, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabo L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brune B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Muller S, Knapp S, Trajanoski Z, Greten FR *. Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses. Cancer Discov. 2023 Jul 25:CD-23-0050. doi: 10.1158/2159-8290.CD-23-0050.
    * corresponding authors


  • 2022

    Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy.
    Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR. Immunity. 2022 Nov 8;55(11):2059-2073.e8. doi: 10.1016/j.immuni.2022.09.014. Epub 2022 Oct 19. PMID: 36351375 Free article.

    Boonsanay, V., Mosa, M.H., Looso, M., Weichenhan, D., Ceteci, F., Pudelko, L., Lechel, A., Michel, C.S., Künne, C., Farin, H.F., Plass, C., Greten, F.R., 2022. Loss of SUV420H2-dependent chromatin compaction drives right-sided colon cancer progression. Gastroenterology.

    Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P.K., Braun, A., Kress, A., Nicolas, A.M., Mohs, K., Becker, C., Neurath, M.F., Farin, H.F., Buchholz, C.J., Andreux, P.A., Rinsch, C., Greten, F.R., 2022. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity, 64.

    Krämer, A., Tjaden, A., Ndreshkjana, B., Tredup, C., Farin, H.F., Knapp, S., Janin, Y.L., Müller, S., 2022. IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH). Current Research in Chemical Biology 2, 100034. Current Research in Chemical Biology. 2022;2:100034.

  • 2021

    Menche C., Farin H.F.
    Strategies for genetic manipulation of adult stem cell-derived organoids.
    Exp Mol Med (2021).
    EMM als Teil der Review Serie Koo, BK: Methods in organoids: a model that goes beyond our imagination. Exp Mol Med (2021).

  • 2020

    Mohammed H. Mosa, Birgitta E. Michels, Constantin Menche, Adele M. Nicolas, Tahmineh Darvishi, Florian R. Greten and Henner F. Farin.
    A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer.
    DOI: 10.1158/0008-5472.CAN-20-0263.
    Cancer Research

    Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR.
    AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.
    J Exp Med (2020) 217.

    Schulz M, Michels B, Niesel K, Stein S, Farin H, Rödel F, Sevenich L.
    Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response.
    iScience 2020:23.
    iScience or download PDF

    Michels BE, Mosa MH, Streibl BI, Zhan T, Menche C, Abou-El-Ardat K, Darvishi T, Członka E, Wagner S, Winter J, Medyouf H. Bourtros M, Farin HF.
    Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.
    Cell Stem Cell 2020, V26, I6: 782-792. E7.
    Cell Stem Cell or download PDF also featured by IDT Decoded Blog

    Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A.
    Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
    The Journal of Biological Chemistry 2020, 295, 4526-4540.

    Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma O-M, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias, G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
    STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
    Gut. 2020, 69(7), 1269-1282.

  • 2019

    Hoang VT, Verma D, Godavarthy PS, Llavona P, Steiner M, Gerlach K, Michels BE, Bohnenberger H, Wachter A, Oellerich T, Müller-Kuller U, Weissenberger E, Voutsinas JM, Oehler VG, Farin HF, Zörnig M, Krause DS.
    The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia 33, 1700-1712, 2019.
    Leukemia by Springer Nature

    Schwiebs A, Juan MHS, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.
    Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
    Oncogene 38, 4788-4803, 2019.
    Oncogene by Springer Nature

    Schnalzger TE, de Groot MH, Zhang C, Mosa MH, Michels BE, Röder J, Darvishi T, Wels WS, Farin HF.
    3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids.
    The EMBO Journal 38: e100928, 2019.
    EMBO or download PDF

    Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF.
    Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.
    J Exp Med. 2019, 216(3):704-720.



    Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D.
    Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. Gastroenterology, 2019, 156(1), 275–278.
    Gastroenterology by AGA institute

  • 2018

    Mosa, M.H., Nicolle, O., Maschalidi, S., Sepulveda, F.E., Bidaud-Meynard, A., Menche, C., Michels, B.E., Michaux, G.*, Basile, G. de S.*, and Farin, H.F.* (2018).
    Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids.
    Cellular and Molecular Gastroenterology and Hepatology, V6/4, S. 477-493.


  • 2017

    Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. (2017).
    YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
    Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27.

  • 2016

    Tetteh, P.W., Kretzschmar, K., Begthel, H., Born, M. van den, Korving, J., Morsink, F., Farin, H., Es, J.H. van, Offerhaus, G.J.A., and Clevers, H. (2016).
    Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.
    PNAS 201614057.

    Greulich, F., Rudat, C., Farin, H.F., Christoffels, V.M., and Kispert, A. (2016).
    Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.
    PLoS ONE 11, e0156787.

    Greulich, F., Trowe, M.-O., Leffler, A., Stoetzer, C., Farin, H.F., and Kispert, A. (2016).
    Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
    J. Mol. Cell. Cardiol. 97, 140–149.

    Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J., Maurice, M.M., et al. (2016). Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature 530, 340–343.

    Tetteh, P.W., Basak, O., Farin, H.F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J.H., et al. (2016). Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell Stem Cell 18, 203–213.


  • 2015

    Weren RDA, Venkatachalam R, Cazier J-B, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ETP, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KKH, Carvajal-Carmona L, Nagtegaal ID, Schackert HK, Clevers H, van de Wetering M, Tomlinson IP, Ligtenberg MJL, Hoogerbrugge N, Geurts van Kessel A, Kuiper RP. (2015)
    Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
    J. Pathol. 236: 155–164

    Tetteh PW, Farin HF, and Clevers H. (2015).
    Plasticity within stem cell hierarchies in mammalian epithelia.
    Trends Cell Biol. Oct 9. pii: S0962-8924(14)00161-5, review article

  • 2014

    Lemoine R, Pachlopnik-Schmid J, Farin HF, Bigorgne A, Debré M, Sepulveda F, Héritier S, Lemale J, Talbotec C, Rieux-Laucat F, Ruemmele F, Morali A, Cathebras P, Nitschke P, Bole-Feysot C, Blanche S, Brousse N, Picard C, Clevers H, Fischer  A, de Saint Basile G. (2014)

    Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency.
    J Allergy Clin Immunol. 134: 1354-1364.

    Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D (2014)
    Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.
    Stem Cell Reports 2: 838–852.

    Farin HF*, Karthaus WR*, Kujala P, Rakhshandehroo M, Vries R, Kalkhoven E, Nieuwenhuis EES, Clevers H.
    Secretion of antimicrobial Paneth cell products is directly controlled by immune cell-derived Interferon-gamma.
    Journal of Experimental Medicine, 2014 Jun 30;211(7):1393-405.

    Yin X, Farin HF, Es JH, Clevers H, Langer R, Karp JM.
    Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
    Nature Methods. 2014 Jan;11(1):106-12. doi: 10.1038/nmeth.2737.

    * = equal contribution

  • 2013

    Bigorgne AE*, Farin HF*, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, Berrebi D, Bole-Feysot C, Nischke P, Brousse N, Fischer A, Clevers H, de Saint Basile G.
    TTC7A mutations disrupt intestinal epithelial apicobasal polarity. Journal of Clinical Investigation.
    2013 Dec 2. pii: 71471. doi: 10.1172/JCI71471. [Epub ahead of print]

    Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ.
    Generation of L-cells in mouse and  human small intestine organoids.
    Diabetes. 2013 Oct 15. [Epub ahead of print]

    de Groot RE, Farin HF, Mac?rková M, van Es JH, Clevers HC, Korswagen HC.
    Retromer dependent recycling of the wnt secretion factor wls is dispensable for stem cell maintenance in the Mammalian intestinal epithelium.
    PLoS One. 2013 Oct  9;8(10):e76971. doi: 10.1371/journal.pone.0076971.

    Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A.
    Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.
    PLoS Genetics. 2013;9(4): e1003467.  doi: 10.1371/journal.pgen.1003467.

    Lüdtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A.
    Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.
    PLoS Genetics. 2013; 9(1):e1003189. doi: 10.1371/journal.pgen.1003189.

  • 2012

    Greulich F, Farin HF, Schuster-Gossler K, Kispert A.
    Tbx18 function in epicardial development.
    Cardiovascular Research. 2012 Dec 1;96(3):476-83. doi: 10.1093/cvr/cvs277.

    Farin HF, Van Es JH, Clevers H.
    Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
    Gastroenterology. 2012 Dec;143(6):1518-1529.e7. doi: 10.1053/j.gastro.2012.08.031.

    Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A.
    Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
    Development. 2012 Sep;139(17):3099-108. doi: 10.1242/dev.077388.

    Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, ‘t Hoen PA, Kispert A, Christoffels VM.
    Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial  cushion formation.
    Cellular and Molecular Life Sciences. 2012 Apr;69(8):1377-89. doi: 10.1007/s00018-011-0884-2.

  • Selected Publications 2007-2011

    Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.
    Controlled gene expression in primary Lgr5 organoid cultures.
    Nature Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802.

    Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A.
    Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme.
    Human Molecular Genetetics 2010 Dec 15;19(24):4918-29. doi: 10.1093/hmg/ddq426.

    Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A.
    Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
    Circulation Research. 2009 Aug 28;105(5):442-52. doi: 10.1161/CIRCRESAHA.109.196063.

    Lausch E, Hermanns P, Farin HF, Alanay Y, Unger S, Nikkel S, Steinwender C, Scherer G, Spranger J, Zabel B, Kispert A, Superti-Furga A.
    TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in  Cousin syndrome.
    American Journal of Human Genetics. 2008 Nov;83(5):649-55. doi: 10.1016/j.ajhg.2008.10.011.

    Farin HF, Mansouri A, Petry M, Kispert A.
    T-box protein Tbx18 interacts with  the paired box protein Pax3 in the development of the paraxial mesoderm.
    Journal of Biological Chemistry. 2008 Sep 12;283(37):25372-80. doi: 10.1074/jbc.M802723200.

    Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A.
    Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
    Journal of Biological Chemistry. 2007 Aug 31;282(35):25748-59.