Fettleibigkeit ist ein wichtiger Risikofaktor für die Entwicklung von Krebs. Obwohl Veränderungen in entzündlichen und bioenergetischen Wegen als Ursache von Krebs aufgrund übermäßiger Gewichtszunahme bekannt sind, gibt es inzwischen genügend Belege die andeuten, dass die Progression der Krankheit mehr mit der Nahrung selbst zu tun hat als mit erhöhter Fettleibigkeit an sich. Die Ernährung wird… [mehr]

Currently about 34 million are infected worldwide by the Human Immunodeficiency Virus (HIV). Although great efforts in the field of highly active antiretroviral therapy (HAART) and especially the introduction of antiviral drugs into countries mostly affected by the epidemic point at a reduction of newly acquired infections and HIV associated mortality, still about 1700 persons… [mehr]

Unsere Arbeitsgruppe am Georg-Speyer-Haus erforscht die molekularen Vorgänge bei der Entstehung von Darmkrebs, insbesondere die Kommunikation verschiedener Zelltypen in der unmittelbaren Umgebung des Tumors, dem so genannten Tumor-Microenvironment. Dabei nutzen wir „Organoide“ ein neuartiges dreidimensionales Gewebekultur-System. Unter definierten Kulturbedingungen bilden sich Organoide aus adulten Stammzellen, die aus endoskopischen Darmbiopsien gewonnen werden können. Dabei bildet das… [mehr]

The notion that chronic inflammatory diseases are associated with an elevated risk of tumorigenesis and Rudolf Virchow’s findings in the late 19th century when he described the high frequency of leucocytes in tumor areas led the basis for genetic studies specifically examining the links between inflammation and cancer that had initially been proposed more than two… [mehr]

Targeting the bone marrow microenvironment as an adjunct to existing therapies Haematological cancers have a high frequency amongst the general population and pose a major health care problem. Significant progress has been made in the treatment of leukaemia. The treatment of chronic myelogenous leukaemia (CML) was revolutionized by targeted therapy in the form of imatinib… [mehr]

Position available as PostDoc – PhD Student – Technician       The Bone Marrow Microenvironment in the Hematopoietic System Under physiological conditions, primitive hematopoietic stem cells (HSCs) reside in anatomically defined areas, referred to as bone marrow niches. The existence of a tightly regulated cross-talk between the complex cellular components of the niche and the HSCs… [mehr]

Brain metastases are the most common cerebral tumor in adults currently affecting up to 30% of cancer patients. Advanced management of primary tumors has led to increased brain metastases incidence over the past years. Despite the severe clinical issue that is associated with brain metastases, current treatment options remain limited and standard of care therapy… [mehr]

Targeted killer cells for cancer immunotherapy Cytotoxic lymphocytes genetically modified to express so-called chimeric antigen receptors (CARs) hold promise for adoptive cancer immunotherapy. CARs are artificial transmembrane proteins that typically contain an extracellular single-chain antibody fragment (scFv) for recognition of antigens on the tumor cell surface, fused to intracellular signaling moieties such as CD3zeta (first… [mehr]