2020
Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels B, Etlioglu E, Yepes D, Häupl B, Ziegler P, Bankov K, Wild P, Wanninger S, Medyouf H, Farin H, Tejpar S, Oellerich T, Ruland J, Siebel C, and Greten F.
AKT dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.
J. Exp. Med. 2020, 217 (10).
JEMMichels BE, Mosa MH, Streibl BI, Zhan T, Menche C, Abou-El-Ardat K, Darvishi T, Członka E, Wagner S, Winter J, Medyouf H, Boutros M, Farin H.
Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.
Cell Stem Cell. V26, I5, 2020, p782-792.e7.
Cell Stem Cell2018
Tirado-Gonzalez I, Czlonka E, Nevmerzhitskaya A, Soetopo D, Bergonzani E, Mahmoud A, Contreras A, Jeremias I, Platzbecker U, Bourquin JP, Kloz U, Van der Hoeven F, Medyouf H.
CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.
Leukemia. 2018 Apr;32(4):1049-1052. doi: 10.1038/leu.2017.346. Epub 2017 Dec 6.
PubMed2017
Schanda J, Lee CW, Wohlan K, Müller-Kuller U, Kunkel H, Coco IQ, Stein S, Metz A, Koch J, Lausen J, Platzbecker U, Medyouf H, Gohlke H, Heuser M, Eder M, Grez M, Scherr M, Wichmann C.
Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.
Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2.
PubMedMedyouf H.
The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications.
Blood. 2017 Mar 23;129(12):1617-1626. doi: 10.1182/blood-2016-11-696070. Epub 2017 Feb 3.
PubMed2016
Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H*, Nowak D*.
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.
Blood. Jun 6. pii: blood-2015-11-679167. [Epub ahead of print]
PubMedBotezatu L, Michel LC, Helness A, Vadnais C, Makishima H, Hönes JM, Robert F, Vassen L, Thivakaran A, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T, Khandanpour C.
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.
Exp Hematol. May 20. pii: S0301-472X(16)30129-1. doi:10.1016/j.exphem. 2016.05.004. [Epub ahead of print]
PubMedKohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.
MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.
PLoS Genet. Mar 18;12(3):e1005946. doi: 10.1371/journal.pgen.1005946. eCollection.
PubMed2015
Ekaterina B, Rauner M, Medyouf H, Theurl I, Bornhauser M , Hofbauer L, Platzbecker U.
Myelodysplasia is in the niche – novel concepts and emerging therapies.
Leukemia. Feb 29(2):259-268.
PubMed2014
Ehninger A, Boch T, Medyouf H, Müdder K, et al.
Loss of SPARC Protects Hematopoietic Stem Cells from Toxicity of Repeated Cycles of Chemotherapy by Accelerating their Return to Quiescence.
Blood. Jun 26;123(26):4054-63.
PubMedMedyouf H, Mossner M, Jann JC, Nolte F, et al.
Myelodysplastic Cells in Patients Re-program Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell-Niche Disease Unit.
Cell Stem Cell. Jun 5;14(6):824-37.
Preview: Raaijmakers M.H (2014) Cell Stem Cell. 13(6): 669-71.
PubMed2006-2013
Medyouf H, Gusscott S, Wang H, Wai C, et al. (2011)
High Level IGF1R Expression is Required for Leukemia-Initiating Cell Activity in T-ALL and is Supported by Notch Signaling.
J Exp Med. 208(9): 1809-22.
PubMedMedyouf H, Gao X, Armstrong F, Gusscott S, et al. (2010)
Acute T-cell Leukemias Remain Dependent on Notch Signaling Despite PTEN and INK4A/ARF Loss.
Blood. 115(6): 1175-84.
PubMedGerby B, Armstrong F, Brunet de la Grange P, Medyouf H, et al. (2010)
Optimized Gene Transfer into Human Primary Leukemic T-cells with NODSCID/Leukemia-Initiating-Cell activity.
Leukemia. 24(3): 646-9.
PubMedMedyouf H and Ghysdael J. (2008)
The Calcineurin/NFAT Signaling Pathway: a Novel Therapeutic Target in Leukemia and Solid Tumors.
Cell Cycle 7(3): 297-303.
PubMedMedyouf H, Alcalde H, Berthier C, Guillemin MC, et al. (2007)
Targeting Calcineurin Activation as a Therapeutic Strategy for Lymphoid Malignancies.
Nat Medicine. (13): 736-741.
Preview: Müller MR, Rao A (2007) Nat. Med. 13(6): 669-71.
PubMedJoliot V, Cormier F, Medyouf H, Alcalde H, et al. (2006)
Constitutive STAT5 Activation Specifically Cooperates with the Loss of p53 Function in B-cell Lymphomagenesis.
Oncogene. 25(33): 4573-84.
PubMed