Research Group Prof. Dr. Melek Canan Arkan
Diet, Energy Metabolism, and Cancer
Metabolic Derangements in Cancer
Cancer is marked by dysregulation of the signaling pathways that orchestrate proliferation, cell death, tumor-promoting inflammation, and bioenergetic pathways. Our studies focus on elucidating the host and tumor energy metabolism in pancreatic and intestinal cancer, delineating the critical alterations that take place during disease and therapy, and targeting the metabolic vulnerability of tumor cells genetically or pharmacologically in relevant preclinical models using; mouse and 3D organoids, which may have a diagnostic value and can impact therapy response.
Imaging in Cancer
Late-stage presentation, inaccessible diagnosis, and resistance to therapy represent the most common causes of increased mortality in cancer patients. Our studies aim at identifying reliable biomarkers for early detection, developing approaches that target defined changes during specific stages of tumor development, progression, and therapy for bioimaging using MRI-detectable smart probes.
Diet, Microbiome, Circadian clock & Cancer
Human gut is inhabited by billions of bacteria contributing majorly to the regulation of metabolic functions and immune homeostasis. Dynamics of microbial community is critical since microbiota composition and functional profiles shape susceptibility to cancer and response to therapy. Nutrition can directly or indirectly modulate microbiome and play a decisive role in disease outcome. Our studies aim at unravelling the impact of dietary intake on microbiota structure and function during cancer and therapy. We elucidate whether precision nutrition can pave the way for individual-based interventions in cancer by regulating microbiome.
Team
The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle.
Arkan MC. Semin Immunol. 2017 Aug;32:35-42. doi: 10.1016/j.smim.2017.08.009. Epub 2017 Sep 1. PMID: 28870704 Review.
Cancer: Fat and the fate of pancreatic tumours.
Arkan MC. Nature. 2016 Aug 11;536(7615):157-8. doi: 10.1038/nature19419. Epub 2016 Aug 3. PMID: 27487208
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC. Nature. 2014 Oct 23;514(7523):508-12. doi: 10.1038/nature13398. Epub 2014 Aug 31. PMID: 25174708 Free PMC article.
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3354-9. doi: 10.1073/pnas.0802864106. Epub 2009 Feb 10. PMID: 19208810
More Publications
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Immunity. 2025 Mar 11;58(3):701-715.e8. doi: 10.1016/j.immuni.2025.02.005. Epub 2025 Feb 28.
ABSTRACT
Expression of interleukin (IL)-17 family cytokines is associated…
Gut microbial carcinogen metabolism: another avenue to cancer
Signal Transduct Target Ther. 2024 Oct 28;9(1):297. doi: 10.1038/s41392-024-02015-8.
NO ABSTRACT
PMID:39468009 | PMC:PMC11519342 | DOI:10.1038/s41392-024-02015-8
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16.
ABSTRACT
Solid cancers exhibit a dynamic balance between cell death and…
IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells
Cell Rep. 2022 Mar 1;38(9):110471. doi: 10.1016/j.celrep.2022.110471.
NO ABSTRACT
PMID:35235803 | DOI:10.1016/j.celrep.2022.110471
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3.
ABSTRACT
Standard cancer therapy targets tumor cells without considering…
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.
ABSTRACT
In colorectal cancer patients, a high density of cytotoxic CD8+ T cells…
The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle
Semin Immunol. 2017 Aug;32:35-42. doi: 10.1016/j.smim.2017.08.009. Epub 2017 Sep 1.
ABSTRACT
The microbial community has a decisive role in determining our health and…
Cancer: Fat and the fate of pancreatic tumours
Nature. 2016 Aug 11;536(7615):157-8. doi: 10.1038/nature19419. Epub 2016 Aug 3.
NO ABSTRACT
PMID:27487208 | DOI:10.1038/nature19419
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Nature. 2014 Oct 23;514(7523):508-12. doi: 10.1038/nature13398. Epub 2014 Aug 31.
ABSTRACT
Several features common to a Western lifestyle, including obesity and low…
IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells
Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29.
ABSTRACT
The recruitment of immune cells into solid tumors is an essential…
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
J Clin Invest. 2013 May;123(5):2231-43. doi: 10.1172/JCI64498. Epub 2013 Apr 8.
ABSTRACT
Chronic pancreatitis is an inflammatory disease that causes progressive…
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27.
ABSTRACT
Cell-type plasticity within a tumor has recently been suggested to cause a…
Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis
Gastroenterology. 2012 Nov;143(5):1361-1374. doi: 10.1053/j.gastro.2012.07.112. Epub 2012 Aug 2.
ABSTRACT
BACKGROUND & AIMS: Little is known about the pathogenic…
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo
J Exp Med. 2010 Nov 22;207(12):2621-30. doi: 10.1084/jem.20100864. Epub 2010 Oct 25.
ABSTRACT
Inhibitor of κB (IκB) β (IκBβ) represents one of the major primary…
IKK- and NF-κB-mediated functions in carcinogenesis
Curr Top Microbiol Immunol. 2011;349:159-69. doi: 10.1007/82_2010_97.
ABSTRACT
Since the initial cloning of RelA and its close relationship to c-Rel, the cellular…
Jobs
Research Technician - Microbiome and Bacterial Cultivation
At the DKTK partner site Frankfurt/Mainz we are looking for a Technical Assistant (m/f/d) for the DKTK Joint Funding Project…
Ph.D. Position in Microbiome, Cancer, and Circadian Rhythm Research
This fully-funded PhD position by the FCI focuses on exploring how the human microbiome interacts with circadian biology to…
Ph.D. Position in Microbiome-derived Factors on CAR-T Cell Therapy Research
This fully-funded Ph.D. position aims to explore how the human microbiome influences cancer biology and immunotherapy,…