Publications
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open
RSC Med Chem. 2024 Nov 29. doi: 10.1039/d4md00735b. Online ahead of print.
ABSTRACT
Target 2035 is a global initiative that seeks to identify a pharmacological modulator…
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir
Nature. 2024 Dec;636(8041):172-181. doi: 10.1038/s41586-024-08163-9. Epub 2024 Nov 13.
ABSTRACT
The bone marrow microenvironment is a critical regulator of…
Establishment of Patient-Derived Organoids from Colorectal Cancer Resection Samples
Methods Mol Biol. 2024 Nov 10. doi: 10.1007/7651_2024_575. Online ahead of print.
ABSTRACT
Colorectal cancer (CRC) organoids can serve as powerful preclinical cell…
Gut microbial carcinogen metabolism: another avenue to cancer
Signal Transduct Target Ther. 2024 Oct 28;9(1):297. doi: 10.1038/s41392-024-02015-8.
NO ABSTRACT
PMID:39468009 | PMC:PMC11519342 | DOI:10.1038/s41392-024-02015-8
Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies
Front Immunol. 2024 Aug 29;15:1457887. doi: 10.3389/fimmu.2024.1457887. eCollection 2024.
ABSTRACT
NKG2D is an activating receptor expressed by natural killer (NK) cells…
T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8
Mol Ther. 2024 Oct 2;32(10):3470-3484. doi: 10.1016/j.ymthe.2024.08.002. Epub 2024 Aug 8.
ABSTRACT
One of the biggest challenges for in vivo gene therapy are vectors…
Fetal growth restriction induced by maternal gal-3 deficiency is associated with altered gut-placenta axis
Cell Death Dis. 2024 Aug 8;15(8):575. doi: 10.1038/s41419-024-06962-6.
ABSTRACT
Adverse intrauterine conditions may cause fetal growth restriction (FGR), a pregnancy…
Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression
Blood Adv. 2024 Oct 8;8(19):4983-4996. doi: 10.1182/bloodadvances.2024012867.
ABSTRACT
Inflammation promotes solid tumor progression, but how regulatory mechanisms of…
ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer
EMBO Rep. 2024 Aug;25(8):3406-3431. doi: 10.1038/s44319-024-00186-7. Epub 2024 Jun 27.
ABSTRACT
The EMT-transcription factor ZEB1 is heterogeneously expressed in tumor…
Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes
Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2312499121. doi: 10.1073/pnas.2312499121. Epub 2024 Jun 10.
ABSTRACT
Ex vivo expansion of human CD34+ hematopoietic stem…
Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis
Neuro Oncol. 2024 Nov 4;26(11):2084-2099. doi: 10.1093/neuonc/noae094.
ABSTRACT
BACKGROUND: Brain metastases (BM) constitute an increasing challenge in oncology due to…
Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors
Mol Ther. 2024 Jul 3;32(7):2357-2372. doi: 10.1016/j.ymthe.2024.05.022. Epub 2024 May 14.
ABSTRACT
Natural killer (NK) cells have high intrinsic cytotoxic capacity, and…
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Nat Commun. 2024 May 15;15(1):4096. doi: 10.1038/s41467-024-48422-x.
ABSTRACT
The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to…
Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation
Mol Ther Oncol. 2024 Apr 11;32(2):200802. doi: 10.1016/j.omton.2024.200802. eCollection 2024 Jun 20.
ABSTRACT
Treatment resistance and immune escape are hallmarks of…
Using the tumour microenvironment to improve therapy efficacy
Nat Rev Cancer. 2024 Jul;24(7):444. doi: 10.1038/s41568-024-00693-8.
NO ABSTRACT
PMID:38671199 | DOI:10.1038/s41568-024-00693-8
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
Nat Cancer. 2024 Jun;5(6):880-894. doi: 10.1038/s43018-024-00749-6. Epub 2024 Apr 24.
ABSTRACT
In this prospective, interventional phase 1 study for individuals with…
Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate
Front Bioeng Biotechnol. 2024 Mar 26;12:1363380. doi: 10.3389/fbioe.2024.1363380. eCollection 2024.
ABSTRACT
INTRODUCTION: Autologous platelet concentrate (APC) are…
Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
Front Cell Infect Microbiol. 2024 Mar 25;14:1363407. doi: 10.3389/fcimb.2024.1363407. eCollection 2024.
ABSTRACT
INTRODUCTION: Influenza A virus (IAV) infection can…
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Nat Cell Biol. 2024 Apr;26(4):593-603. doi: 10.1038/s41556-024-01387-x. Epub 2024 Mar 29.
ABSTRACT
Loss of protein function is a driving force of ageing. We have…
Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche
Leukemia. 2024 May;38(5):936-946. doi: 10.1038/s41375-024-02226-6. Epub 2024 Mar 21.
ABSTRACT
Clonal hematopoiesis (CH) defines a premalignant state predominantly found…
Future direction of total neoadjuvant therapy for locally advanced rectal cancer
Nat Rev Gastroenterol Hepatol. 2024 Jun;21(6):444-455. doi: 10.1038/s41575-024-00900-9. Epub 2024 Mar 14.
ABSTRACT
Despite therapeutic advancements, disease-free…
Biophysical Investigation of RNA ⋅ DNA : DNA Triple Helix and RNA : DNA Heteroduplex Formation by the lncRNAs MEG3 and Fendrr
Chembiochem. 2024 May 17;25(10):e202400049. doi: 10.1002/cbic.202400049. Epub 2024 Apr 29.
ABSTRACT
Long non-coding RNAs (lncRNAs) are important regulators of gene…
Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies
NPJ Genom Med. 2024 Mar 1;9(1):18. doi: 10.1038/s41525-024-00398-9.
ABSTRACT
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals…
A guideline on the molecular ecosystem regulating ferroptosis
Nat Cell Biol. 2024 Sep;26(9):1447-1457. doi: 10.1038/s41556-024-01360-8. Epub 2024 Feb 29.
ABSTRACT
Ferroptosis, an intricately regulated form of cell death…
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
J Immunother Cancer. 2024 Feb 27;12(2):e008155. doi: 10.1136/jitc-2023-008155.
ABSTRACT
BACKGROUND: The antitumor activity of natural killer (NK) cells can be enhanced…
Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine
Cell Mol Gastroenterol Hepatol. 2024;17(6):1072-1075. doi: 10.1016/j.jcmgh.2024.02.011. Epub 2024 Feb 16.
NO ABSTRACT
PMID:38369130 | PMC:PMC11127621 | DOI:10.1016/j.jcmgh.2024.02.011
Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
Cells. 2024 Jan 28;13(3):246. doi: 10.3390/cells13030246.
ABSTRACT
NKG2D is an activating receptor of natural killer cells that recognizes stress-induced ligands…
Tumor-host cell interaction in the microenvironment: new target points for treatment?
Nervenarzt. 2024 Feb;95(2):104-110. doi: 10.1007/s00115-023-01604-2. Epub 2024 Jan 5.
ABSTRACT
BACKGROUND: Primary brain tumors and metastases in the central nervous…
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
J Clin Invest. 2023 Dec 28;134(5):e169576. doi: 10.1172/JCI169576.
ABSTRACT
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease…
The activating receptor NKp65 is selectively expressed by human ILC3 and demarcates ILC3 from mature NK cells
Eur J Immunol. 2024 Apr;54(4):e2250318. doi: 10.1002/eji.202250318. Epub 2024 Feb 26.
ABSTRACT
Innate lymphocytes comprise cytotoxic natural killer (NK) cells and…
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
iScience. 2023 Nov 4;26(12):108399. doi: 10.1016/j.isci.2023.108399. eCollection 2023 Dec 15.
ABSTRACT
Precision oncology approaches for patients with colorectal cancer…
Dataset of single nucleotide polymorphisms of immune-associated genes in patients with SARS-CoV-2 infection
PLoS One. 2023 Nov 16;18(11):e0287725. doi: 10.1371/journal.pone.0287725. eCollection 2023.
ABSTRACT
The SARS-CoV-2 pandemic has affected nations globally leading to…
PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia
Leukemia. 2023 Dec;37(12):2367-2382. doi: 10.1038/s41375-023-02041-5. Epub 2023 Nov 7.
ABSTRACT
High metabolic flexibility is pivotal for the persistence and therapy…
The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males
Nat Commun. 2023 Nov 2;14(1):7024. doi: 10.1038/s41467-023-42760-y.
ABSTRACT
After myocardial infarction in the adult heart the remaining, non-infarcted tissue adapts to…
Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer
Front Immunol. 2023 Oct 11;14:1254821. doi: 10.3389/fimmu.2023.1254821. eCollection 2023.
ABSTRACT
Natural killer (NK) cells are attractive effectors for adoptive…
Distinct and targetable role of calcium-sensing receptor in leukaemia
Nat Commun. 2023 Oct 6;14(1):6242. doi: 10.1038/s41467-023-41770-0.
ABSTRACT
Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they…
Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial
Leukemia. 2023 Nov;37(11):2309-2313. doi: 10.1038/s41375-023-02029-1. Epub 2023 Sep 21.
NO ABSTRACT
PMID:37735558 | PMC:PMC10624604 | DOI:10.1038/s41375-023-02029-1
Towards more Diversity in Neuro-oncology Leadership-the DivINe Initiative
Neuro Oncol. 2023 Dec 8;25(12):2302-2304. doi: 10.1093/neuonc/noad157.
NO ABSTRACT
PMID:37738478 | PMC:PMC10708925 | DOI:10.1093/neuonc/noad157
Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD2-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2
Cancers (Basel). 2023 Aug 29;15(17):4310. doi: 10.3390/cancers15174310.
ABSTRACT
In contrast to T lymphocytes, natural killer (NK) cells do not require prior…
ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma
Front Immunol. 2023 Aug 18;14:1228894. doi: 10.3389/fimmu.2023.1228894. eCollection 2023.
ABSTRACT
INTRODUCTION: Metastatic rhabdomyosarcoma (RMS) is a challenging tumor…
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches
Immunity. 2023 Aug 8;56(8):1704-1706. doi: 10.1016/j.immuni.2023.07.010.
ABSTRACT
Hypoxia is a major driver of tumor aggressiveness and therapy resistance in GBM. In…
Live-cell imaging for analysis of the NK cell immunological synapse
Methods Cell Biol. 2023;178:1-12. doi: 10.1016/bs.mcb.2022.09.023. Epub 2022 Nov 12.
ABSTRACT
The immunological synapse (IS) between NK cells and cancer cells is…
Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Cancer Discov. 2023 Oct 5;13(10):2192-2211. doi: 10.1158/2159-8290.CD-23-0050.
ABSTRACT
In colorectal cancers, the tumor microenvironment plays a key role in prognosis…
Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement
J Allergy Clin Immunol. 2023 Oct;152(4):949-960. doi: 10.1016/j.jaci.2023.06.016. Epub 2023 Jun 29.
ABSTRACT
BACKGROUND: The actin cytoskeleton has a crucial role in the…
The Brain Pre-Metastatic Niche: Biological and Technical Advancements
Int J Mol Sci. 2023 Jun 13;24(12):10055. doi: 10.3390/ijms241210055.
ABSTRACT
Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and…
Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure
Am J Physiol Cell Physiol. 2023 Jul 1;325(1):C129-C140. doi: 10.1152/ajpcell.00101.2023. Epub 2023 Jun 5.
ABSTRACT
Liver cirrhosis is the end stage of all chronic liver…
Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element
Nucleic Acids Res. 2023 Jul 7;51(12):6227-6237. doi: 10.1093/nar/gkad395.
ABSTRACT
Long non-coding RNAs are a very versatile class of molecules that can have important…
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma
Neuro Oncol. 2023 Nov 2;25(11):2058-2071. doi: 10.1093/neuonc/noad087.
ABSTRACT
BACKGROUND: Glioblastoma (GB) is incurable at present without established treatment…
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
Nat Commun. 2023 Apr 3;14(1):1722. doi: 10.1038/s41467-023-36764-x.
ABSTRACT
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor…
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
ACS Chem Biol. 2023 Apr 21;18(4):822-836. doi: 10.1021/acschembio.2c00877. Epub 2023 Mar 21.
ABSTRACT
Well-characterized small molecules are essential tools for studying…
Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy
Sci Adv. 2023 Mar 17;9(11):eadd8564. doi: 10.1126/sciadv.add8564. Epub 2023 Mar 15.
ABSTRACT
Immune checkpoint inhibitors (ICIs) enhance anticancer immunity by releasing…
Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids
Mol Oncol. 2023 Aug;17(8):1545-1566. doi: 10.1002/1878-0261.13414. Epub 2023 Mar 9.
ABSTRACT
Control of tumour development and growth by the immune system critically…
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Gut. 2023 Sep;72(9):1774-1782. doi: 10.1136/gutjnl-2022-327909. Epub 2023 Jan 27.
ABSTRACT
OBJECTIVE: Investigating the effect of ferroptosis in the tumour…
Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers
Cancer Immunol Immunother. 2023 Sep;72(9):2905-2918. doi: 10.1007/s00262-023-03374-x. Epub 2023 Jan 23.
ABSTRACT
Chimeric antigen receptor (CAR)-engineered immune…
Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis
Mol Cell. 2022 Dec 15;82(24):4588-4590. doi: 10.1016/j.molcel.2022.11.020.
ABSTRACT
Chai et al.1 reveal that the eukaryotic-like effector protein PtpB from Mycobacterium…
Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity
Clin Cancer Res. 2023 Mar 14;29(6):1009-1016. doi: 10.1158/1078-0432.CCR-22-1031.
ABSTRACT
Tumor-associated inflammation (TAI) is a feature of essentially all cancers…
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16.
ABSTRACT
Solid cancers exhibit a dynamic balance between cell death and…
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
J Med Genet. 2023 Jun;60(6):587-596. doi: 10.1136/jmg-2022-108738. Epub 2022 Nov 15.
ABSTRACT
BACKGROUND: SHROOM4 is thought to play an important role in cytoskeletal…
Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer
J Pathol Clin Res. 2023 Jan;9(1):73-85. doi: 10.1002/cjp2.300. Epub 2022 Nov 8.
ABSTRACT
Tumor stem cells play a pivotal role in carcinogenesis and metastatic spread in…
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Immunity. 2022 Nov 8;55(11):2059-2073.e8. doi: 10.1016/j.immuni.2022.09.014. Epub 2022 Oct 19.
ABSTRACT
T memory stem cells (TSCM) display increased self-renewal and…
A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy
Commun Biol. 2022 Nov 9;5(1):1203. doi: 10.1038/s42003-022-04092-3.
ABSTRACT
Classic bladder exstrophy represents the most severe end of all human congenital anomalies…
AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma
Oncoimmunology. 2022 Oct 11;11(1):2127508. doi: 10.1080/2162402X.2022.2127508. eCollection 2022.
ABSTRACT
Glioblastoma (GB) is the most common primary brain tumor, which…
HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
Cells. 2022 Sep 23;11(19):2968. doi: 10.3390/cells11192968.
ABSTRACT
Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major…
Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies
Leukemia. 2022 Nov;36(11):2734-2738. doi: 10.1038/s41375-022-01705-y. Epub 2022 Oct 8.
NO ABSTRACT
PMID:36209321 | PMC:PMC9613475 | DOI:10.1038/s41375-022-01705-y
Image-guided radiotherapy in an orthotopic mouse model of rectal cancer
STAR Protoc. 2022 Dec 16;3(4):101749. doi: 10.1016/j.xpro.2022.101749. Epub 2022 Oct 5.
ABSTRACT
Radiobiology research in rectal cancer has been limited to cell lines,…
Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression
Blood Adv. 2023 Apr 11;7(7):1190-1203. doi: 10.1182/bloodadvances.2022007528.
ABSTRACT
Leukemia cells reciprocally interact with their surrounding bone marrow…
Extracellular Vesicles in Myeloid Neoplasms
Int J Mol Sci. 2022 Aug 8;23(15):8827. doi: 10.3390/ijms23158827.
ABSTRACT
Myeloid neoplasms arise from malignant primitive cells, which exhibit growth advantage within…
Inflammation: the incubator of the tumor microenvironment
Trends Cancer. 2022 Nov;8(11):901-914. doi: 10.1016/j.trecan.2022.07.002. Epub 2022 Jul 28.
ABSTRACT
An inflammatory microenvironment, either conferred by an underlying…
Walking the Tightrope: Balancing Delicate Inflammation Response to Eradicate Acute Myeloid Leukemia
Cancer Discov. 2022 Jul 6;12(7):1617-1619. doi: 10.1158/2159-8290.CD-22-0473.
ABSTRACT
Ellegast and colleagues show that monocytic acute myeloid leukemias (AML),…
The splicing-regulatory lncRNA NTRAS sustains vascular integrity
EMBO Rep. 2022 Jun 7;23(6):e54157. doi: 10.15252/embr.202154157. Epub 2022 May 8.
ABSTRACT
Vascular integrity is essential for organ homeostasis to prevent edema…
The EHA Research Roadmap: Hematopoietic Stem Cells and Allotransplantation
Hemasphere. 2022 Apr 29;6(5):e0714. doi: 10.1097/HS9.0000000000000714. eCollection 2022 May.
NO ABSTRACT
PMID:35509429 | PMC:PMC9061153 | DOI:10.1097/HS9.0000000000000714
ACO/ARO/AIO-21 - Capecitabine-based chemoradiotherapy in combination with the IL-1 receptor antagonist anakinra for rectal cancer Patients: A phase I trial of the German rectal cancer study group
Clin Transl Radiat Oncol. 2022 Apr 6;34:99-106. doi: 10.1016/j.ctro.2022.04.003. eCollection 2022 May.
ABSTRACT
PURPOSE: Recent advances in the treatment algorithm of…
Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation
Cancer Res. 2022 Apr 15;82(8):1617-1632. doi: 10.1158/0008-5472.CAN-20-3870.
ABSTRACT
An altered lipidome in tumors may affect not only tumor cells themselves but also…
Targeting IL-1β in patients with advanced Helicobacter pylori infection: a potential therapy for gastric cancer
Future Microbiol. 2022 May;17:633-641. doi: 10.2217/fmb-2021-0242. Epub 2022 Mar 24.
ABSTRACT
Helicobacter pylori (H. pylori) infection is a causal factor of gastric…
The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia
Blood Adv. 2022 Jun 28;6(12):3611-3624. doi: 10.1182/bloodadvances.2021005992.
ABSTRACT
Lipid raft-associated proteins play a vital role in membrane-mediated processes.…
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Cell Death Dis. 2022 Mar 4;13(3):204. doi: 10.1038/s41419-022-04659-2.
ABSTRACT
Specialized surveillance mechanisms are essential to maintain the genetic integrity of…
Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical Heterogeneity
Cancers (Basel). 2022 Jan 25;14(3):603. doi: 10.3390/cancers14030603.
ABSTRACT
Breast cancer is a heterogeneous disease and the mechanistic framework for differential…
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3.
ABSTRACT
Standard cancer therapy targets tumor cells without considering…
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Nat Cancer. 2021 Oct;2(10):1086-1101. doi: 10.1038/s43018-021-00254-0. Epub 2021 Oct 18.
ABSTRACT
Tumor microenvironment-targeted therapies are emerging as promising…
Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis
Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116.
ABSTRACT
The activation and differentiation of cancer-associated fibroblasts (CAF) are…
Tumor-associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance
Eur J Immunol. 2022 Nov;52(11):1750-1758. doi: 10.1002/eji.202149487. Epub 2022 Feb 24.
ABSTRACT
DCs play a pivotal role in orchestrating innate and adaptive antitumor…
CD33 Delineates Two Functionally Distinct NK Cell Populations Divergent in Cytokine Production and Antibody-Mediated Cellular Cytotoxicity
Front Immunol. 2022 Jan 4;12:798087. doi: 10.3389/fimmu.2021.798087. eCollection 2021.
ABSTRACT
The generation and expansion of functionally competent NK cells in vitro…
Immune Checkpoint Inhibitor-Induced Cerebral Pseudoprogression: Patterns and Categorization
Front Immunol. 2022 Jan 3;12:798811. doi: 10.3389/fimmu.2021.798811. eCollection 2021.
ABSTRACT
BACKGROUND: The inclusion of immune checkpoint inhibitors (ICIs) in…
Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity
Oncoimmunology. 2021 Oct 19;10(1):1973783. doi: 10.1080/2162402X.2021.1973783. eCollection 2021.
ABSTRACT
Intratumoral heterogeneity is frequently associated with tumor…
The EHA Research Roadmap: Normal Hematopoiesis
Hemasphere. 2021 Nov 30;5(12):e669. doi: 10.1097/HS9.0000000000000669. eCollection 2021 Dec.
NO ABSTRACT
PMID:34853826 | PMC:PMC8615310 | DOI:10.1097/HS9.0000000000000669
KMT9 Controls Stemness and Growth of Colorectal Cancer
Cancer Res. 2022 Jan 15;82(2):210-220. doi: 10.1158/0008-5472.CAN-21-1261. Epub 2021 Nov 4.
ABSTRACT
Colorectal cancer is among the leading causes of cancer-associated…
Strategies for genetic manipulation of adult stem cell-derived organoids
Exp Mol Med. 2021 Oct;53(10):1483-1494. doi: 10.1038/s12276-021-00609-8. Epub 2021 Oct 18.
ABSTRACT
Organoid technology allows the expansion of primary epithelial cells…
Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity
J Immunother Cancer. 2021 Oct;9(10):e002980. doi: 10.1136/jitc-2021-002980.
ABSTRACT
BACKGROUND: Natural killer group 2D (NKG2D) is an activating receptor of natural…
Zinc accelerates respiratory burst termination in human PMN
Redox Biol. 2021 Nov;47:102133. doi: 10.1016/j.redox.2021.102133. Epub 2021 Sep 17.
ABSTRACT
The respiratory burst of phagocytes is essential for human survival. Innate…
TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man
Front Immunol. 2021 Sep 3;12:716504. doi: 10.3389/fimmu.2021.716504. eCollection 2021.
ABSTRACT
Macrophages not only represent an integral part of innate immunity but…
Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial
Eur J Nutr. 2022 Feb;61(1):477-487. doi: 10.1007/s00394-021-02666-1. Epub 2021 Sep 6.
ABSTRACT
PURPOSE: The prospective, randomized ERGO2 trial investigated the effect…
The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13
Blood. 2021 Nov 11;138(19):1870-1884. doi: 10.1182/blood.2021011557.
ABSTRACT
B-cell acute lymphoblastic leukemia (B-ALL) occurs most commonly in children, whereas…
AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia
Cancer Discov. 2021 Nov;11(11):2924-2943. doi: 10.1158/2159-8290.CD-20-1378. Epub 2021 Jun 8.
ABSTRACT
Acute leukemias are systemic malignancies associated with a dire…
Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations
Int J Mol Sci. 2021 May 11;22(10):5055. doi: 10.3390/ijms22105055.
ABSTRACT
Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and…
PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1
Oncogenesis. 2021 May 17;10(5):42. doi: 10.1038/s41389-021-00332-z.
ABSTRACT
The establishment of cell type specific gene expression by transcription factors and their…
Recent advances in understanding chronic myeloid leukemia: where do we stand?
Fac Rev. 2021 Apr 1;10:35. doi: 10.12703/r/10-35. eCollection 2021.
ABSTRACT
While the need for complete eradication of leukemic stem cells (LSCs) in chronic myeloid…
The inflammatory pathogenesis of colorectal cancer
Nat Rev Immunol. 2021 Oct;21(10):653-667. doi: 10.1038/s41577-021-00534-x. Epub 2021 Apr 28.
ABSTRACT
The mutational landscape of colorectal cancer (CRC) does not enable…
Expression of Potential Targets for Cell-Based Therapies on Melanoma Cells
Life (Basel). 2021 Mar 24;11(4):269. doi: 10.3390/life11040269.
ABSTRACT
Tumor antigen-specific redirection of cytotoxic T cells (CTLs) or natural killer (NK) cells…
Retargeting of NK-92 Cells against High-Risk Rhabdomyosarcomas by Means of an ERBB2 (HER2/Neu)-Specific Chimeric Antigen Receptor
Cancers (Basel). 2021 Mar 22;13(6):1443. doi: 10.3390/cancers13061443.
ABSTRACT
The dismal prognosis of pediatric and young adult patients with high-risk…
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis
EMBO Mol Med. 2021 May 7;13(5):e13412. doi: 10.15252/emmm.202013412. Epub 2021 Mar 23.
ABSTRACT
The tumor microenvironment in brain metastases is characterized by high…