Selected Publications

Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, Pereira RS, Tascher G, Tertel T, Covvarubias-Pinto A, Bankov K, Pfeffermann L-M, Bonig H, Divieti-Pajevic P, McEwan DG, , Giebel B, Münch C, Dikic I, Krause DS
Impact of mesenchymal stromal cell-derived exosomal cargo on B-cell acute lymphoblastic leukemia progression
Blood Adv. 2022 Aug 31:bloodadvances.2022007528. doi: 10.1182/bloodadvances.2022007528. Online ahead of print

Kumar R, Pereira RS, Niemann J, Azimpour AI, Zanetti C, Karantanou C, Minka W, Minciacchi VR, Kowarz E, Meister M, Godavarthy PS, Maguer-Satta V, Lefort S, Wiercinska E, Bonig H, Marschalek R, Krause DS
The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia
Blood Adv. 2022 Jun 28;6(12):3611-3624.

Zanetti C, Kumar R, Ender J, Godavarthy PS, Hartmann M, Hey J, Breuer K, Weissenberger ES, Minciacchi V, Karantanou C, Gu Z, Roberts KG, Metzler M, Stock W, Mullighan CG, Bloomfield CD, Filmann N, Bankov K, Hartmann S, Hasserjian RP, Cousins A, Halsey C, Plass C, Lipka DB, Krause DS
The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL3
Blood. 2021;138(19):1870-1884

Gubas A*, Karantanou C*, Popovic D, Tascher G, Hoffmann ME, Dawe N, Dikic I, Krause DS, McEwan DG. The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.
FEBS Lett. 2021 Apr;595(7):864-880.

Kumar R, Pereira R, Zanetti C, Minciacchi VR, Merten M, Meister M, Niemann J, Dietz MS, Rüssel N, Schnütgen F, Tamai M, Akahane K, Inukai T, Oellerich T, Kvasnicka HM, Pfeifer H, Nicolini FE, Heilemann M, Van Etten RA, Krause DS. Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia
Leukemia. 2020, 34(8):2087-2101

Verma D*, Zanetti C*, Godavarthy PS*, Kumar R, Minciacchi VR, Pfeiffer J, Metzler M, Lefort S, Maguer-Satta V, Nicolini FE, Burroni B, Fontenay M, Krause DS
Bone marrow niche-derived extracellular matrix-degrading enzymes influence the progression of B-cell acute lymphoblastic leukemia
Leukemia. 2020 Jun;34(6):1540-1552.

Godavarthy PS, Kumar R, Herkt SC, Pereira RS, Hayduk N, Weissenberger ES, Aggoune D, Manavski Y, Lucas T, Pan K-T, Voutsinas JM, Wu Q, Müller MC, Saussele S, Oellerich T, Oehler VG, Lausen J, Krause DS
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin – SCL/TAL1 – CD44 axis
Haematologica. 2020 Jan;105(1):136-147

Hoang VT+, Verma D+, Godavarthy PS, Llavona P, Steiner M, Gerlach K, Michels BE, Bohnenberger H, Wachter A, Oellerich T, Müller-Kuller U, Weissenberger E, Voutsinas JM, Oehler VG, Farin HF, Zörnig M*, Krause DS*. *shared last co-authourship
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia
Leukemia, 2019 Jul;33(7):1700-1712

Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunst K, Hoelper S, Zia-Chahabi S, Jabagi M-J, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Divieti-Pajevic P, Krause DS
Vitamin K-antagonism impairs the bone marrow microenvironment and hematopoiesis
Blood. 2019, 134(3):227-238

Naka K, Ishihara K, Jomen Y, Jin CH, Kim DH, Gu YK, Jeong ES, Li S, Krause DS, Kim DW, Bae E, Takihara Y, Hirao A, Oshima H, Oshima M, Ooshima A, Sheen YY, Kim SJ, Kim DK.
Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.
Cancer Sci. 2016 Feb;107(2):140-8. doi: 10.1111/cas.12849. Epub 2016 Jan 26.
PubMed

Rabenhorst U, Thalheimer F, Gerlach K, Kijonka M, Böhm S, Krause DS, Vauti F, Arnold HH, Schroeder T, Schnütgen F, von Melchner H, Rieger M, Zörnig M
Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal
Cell Rep. 2015 Jun 30;11(12):1847-55.
PubMed

Publications – Reviews, editorials, letters to the editor:
Krause DS, Dikic I
Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis
Mol Cell, 2022 Dec 15;82(24):4588-4590

Kumar R, Krause DS
Recent advances in understanding chronic myeloid leukemia – where do we stand?
Faculty Reviews. 2021, 10(35)

Méndez-Ferrer S, Bonnet D, Steensma DP, Hasserjian RP, Ghobrial IM, Gribben JG, Andreeff M, Krause DS
Bone marrow niches in haematological malignancies.
Nat Rev Cancer, 2020, May;20(5):285-298.

Zanetti C, Krause DS
“Caught in the net” – the extracellular matrix of the bone marrow in normal haematopoiesis and leukaemia
Exp Hematol. 2020 Sep;89:13-25

Kumar R*, Minciacchi VR*, Krause DS
Chronic myeloid leukemia – a model disease of the past, presence and future
Cells. 2021 Jan 10;10(1):117. doi: 10.3390/cells10010117.

Krause DS, Divieti-Pajevic P
Osteocyte Regulation of Bone and Blood
Bone. 2019 Feb;119:13-18

Kumar R, Godavarthy PS, Krause DS
The bone marrow microenvironment in health and disease at a glance
J Cell Sci. 2018 Feb 22;131(4). pii: jcs201707

Karantanou C, Godavarthy PS, Krause DS
Targeting the bone marrow microenvironment in acute leukaemia
Leuk Lymphoma. 2018 Feb 12:1-11

Krause DS, Scadden DT
A hostel for the hostile: The stem cell niche in haematological neoplasms
Haematologica 2015;100(11):1376-87

Krause DS
Illness and artistic creativity (on the 70th anniversary of the death of Béla Bartók, composer, ethnomusicologist and leukemia patient).
Leukemia 2015;29(12):2417-8

Masia R, Krause DS, Yellen G.
The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Am J Physiol Cell Physiol. 2015 Feb 1;308(3):C264-76.
PubMed

Wheat JC*, Krause DS*, Shin TH*, Chen X, Wang J, Ding D, Yasmin R, Sweetser DA.
The corepressor Tle4 is a novel regulator of murine hematopoietic stem and progenitor cells and their niche.
PLoS One. 2014 Aug 25;9(8):e105557. doi: 10.1371/journal.pone.0105557. eCollection 2014.
PubMed

Krause DS, Lazarides K, Lewis JB, von Andrian UH, Van Etten RA.
Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche
Blood 2014; 123(9): 1361-1371
PubMed

Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT
Differential regulation of myeloid leukemias by the bone marrow microenvironment
Nature Medicine 2013; 19(11):1513-1517* *Faculty of 1000 Prime status
PubMed

Fulzele K*, Krause DS*, Panaroni C, Saini V, Barry KJ, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti-Pajevic P
Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling
Blood 2013 Feb 7;121(6):930-9.
PubMed

Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees J, Fuchs TA, Scadden DT, Wagner DD
Cancer predisposes neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis
Proc Natl Acad Sci U S A 2012; 109(32):13076
PubMed

Krause DS, Spitzer TR, Stowell CP
The concentration of CD44 is increased in hematopoietic stem cell grafts of patients with acute myeloid leukemia, plasma cell myeloma, and non-Hodgkin lymphoma.
Arch Pathol Lab Med 2010; 134(7): 1033-8
PubMed

Krause DS, Lazarides K, von Andrian UH, Van Etten RA.
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
Nat Med 2006; 12 (10):1175-80
PubMed

Krause DS, Van Etten RA.
Adoptive Immunotherapy of Bcr/Abl-induced chronic myeloid leukemia-like myeloproliferative disease in a murine model.
Blood 2004; 104: 4236-4244.
PubMed

Roumiantsev S*, Krause DS*, Neumann CA, Dimitri CA, Asiedu F, Cross NCP, Van Etten RA.
Distinct stem cell myeloproliferative /T-lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
Cancer Cell 2004;5:287-298
PubMed

Publications – Book chapters:

Weissenberger ES, Krause DS
Histological and In Vivo Microscopic Analysis of the Bone Marrow Microenvironment in a Murine Model of Chronic Myelogenous Leukemia
Methods Mol Biol. 2016;1465:59-72

Krause DS, DeLelys ME, Preffer FI
Flow Cytometry for Hematopoietic Cells
Methods Mol Biol 2014; 1109:23-46

Verma D, Krause DS
Targeting the bone marrow niche in haematological malignancies
Advances in Stem Cells and Their Niches volume 1, in press