Forschen für das Leben
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,
Georg-Speyer-Haus. Foto: Andreas Reeg, Tel: +40-171-5449247,,

In Western countries one in two men and one in three women will develop a malignant tumor during their life. In Germany over 500.000 new cases were diagnosed and over 230.000 patients succumbed to their disease in 2019. Because of the increasing number of senior citizens these numbers are likely to increase further in the coming years. The development of new effective strategies to treat and prevent cancer remains a great challenge.

The Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, aims to decipher the molecular and cellular basis of tumorigenesis. A particular focus is placed on the analysis and the interaction of various cell types within the tumor, the tumor microenvironment. New therapeutic concepts are being tested in valid pre-clinical tumor models. In close collaboration with the University Cancer Center (UCT) and the LOEWE Center Frankfurt Cancer Institute (FCI) as well as a member of the German Cancer Consortium (DKTK) these concepts are translated into early clinical trials. At our institute we pursue this translational research – from basic research on tumor biology to preclinical studies – by 3 research fields:


  • Cellular Communication in the Stem Cell Niche

Learn more in the laboratories of Prof. Dr. Krause and Dr. Medyouf

  • Cell-Cell Interaction in the Tumor Stroma

Learn more in the laboratories of Dr. Arkan, Dr. Farin, Prof. Dr. Greten and Dr. Sevenich

  • Experimental Therapy

Learn more in the lab of Prof. Dr. Wels

Our institute is available to host MSCA postdoctoral fellows. We welcome top-level multidisciplinary postdoctoral researchers in areas like biology, medicine, biotechnology, pharmacology or bioinformatics, regardless of nationality, who are interested in applying for an EU-funded Marie Sklodowska Curie Actions (MSCA) Postdoctoral Fellowship. See our ads on Euraxess and KoWi websites and find calls for funding MSCA actions under this link. If you are considering applying for such funding, please contact an appropriate group leader, preferably well in advance of the deadline, present your project idea, develop it into a full MSCA proposal together with the host, and apply for funding from the European Commission. The Institute offers administrative support for EU projects.

Read below our annual reports of the latest years 2015-2020 and get to know more about the Georg-Speyer-Haus and the state of research at our Institute for Tumor Biology and Experimental Therapy.