Research
Our research focuses on unraveling the complexity of the interplay between cancer and stromal cells in the tumor microenvironment (TME), as tumors erect multiple barriers to evade immune destruction, resulting in non-responsiveness to treatments. Therefore, we are delving into the roles and regulation of suppressive cell populations to identify vulnerabilities in cancer and stromal cell crosstalk that can be targeted therapeutically….
Gautami completed BSc (Blended) in Bioscience, a special degree granted by Savitribai Phule Pune University (India) and designed by University of Melbourne (Australia). Later during the training at IISER Pune (India), she studied the role of Api5 protein in breast carcinogenesis and explored her joint interest in molecular and cancer biology. In 2023, she was… [mehr]
Leoni received her Bachelor’s degree in Biology from the Technical University of Darmstadt, where she investigated immunogenicity of cell death at the GSI Helmholtz Center for Heavy Ion Research for her thesis. In her Master thesis in the group of Dr. Tatarova, she explored histopathology staining methods and bioinformatic tools to study resistance mechanisms in… [mehr]
DKTK Research Group for Therapy Resistance Systems Biology of Breast Cancer in Therapy Resistance Recent integration of tumor devices and high-dimensional computational data from mouse mammary carcinoma studies re-enforced the concept that cancer neighborhood (local tumor microenvironment, TME) can determine efficacy of anti-cancer therapies. We hypothesize that achieving durable cancer control will require systematic… [mehr]
Anna Wolfram completed her Bachelor’s and Master’s degree in Biochemistry at the University of Heidelberg. Anne specialized on the multidisciplinary process of drug design in both her bachelor’s and master’s thesis. For the former, she worked on hypoxia activated prodrugs in the Translational Therapeutics Team (ACSRC, New Zealand). For the later, Anna worked on the… [mehr]